3,3-difluoro-5-hydroxy-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

Base Information

Chemical Name:3,3-difluoro-5-hydroxy-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester
CAS No.:746641-83-8
Molecular Formula:C₁₇H₂₁F₂NO₅
Molecular Weight:357.354
Hs Code.:

3,3-difluoro-5-hydroxy-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-<i>tert</i>-butyl ester

Synonyms:3,3-difluoro-5-hydroxy-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

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Chemical Property of 3,3-difluoro-5-hydroxy-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

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Technology Process of 3,3-difluoro-5-hydroxy-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

There total 5 articles about 3,3-difluoro-5-hydroxy-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 746641-76-9
benzyl (R)-2-[N-(tert-butoxycarbonyl)amino]-3,3-difluoro-5-hexenoate

: 746641-83-8
3,3-difluoro-5-hydroxy-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

Guidance literature:: benzyl (R)-2-[N-(tert-butoxycarbonyl)amino]-3,3-difluoro-5-hexenoate; With ozone; In dichloromethane; at -78 ℃;

With dimethylsulfide; In dichloromethane; at -78 - 20 ℃; for 12h;
DOI:10.1021/jo049789c

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 746641-83-8
3,3-difluoro-5-hydroxy-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: Na₂S₂O₃; NaHCO₃ / acetonitrile; H₂O / 8 h / 0 - 30 °C

2.1: ozone / CH₂Cl₂ / -78 °C

2.2: Me₂S / CH₂Cl₂ / 12 h / -78 - 20 °C

With sodium hydrogencarbonate; ozone; sodium thiosulfate; In dichloromethane; water; acetonitrile;
DOI:10.1021/jo049789c

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 746641-83-8
3,3-difluoro-5-hydroxy-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 3-chloro-1-hydroxytetrabutyldistannoxane / toluene / 12 h / Heating

2.1: CAN; water / acetonitrile / 0.5 h / 0 °C

3.1: Na₂S₂O₃; NaHCO₃ / acetonitrile; H₂O / 8 h / 0 - 30 °C

4.1: ozone / CH₂Cl₂ / -78 °C

4.2: Me₂S / CH₂Cl₂ / 12 h / -78 - 20 °C

With ammonium cerium(IV) nitrate; water; sodium hydrogencarbonate; ozone; sodium thiosulfate; 1-chloro-3-hydroxy-1,1,3,3-tetrabutyldistannoxane; In dichloromethane; water; toluene; acetonitrile;
DOI:10.1021/jo049789c