N-(tert-butoxycarbonyl)-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine methyl ester

Base Information

• Chemical Name: N-(tert-butoxycarbonyl)-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine methyl ester
• CAS No.: 86778-92-9
• Molecular Formula: C₂₂H₃₄N₆O₇
• Molecular Weight: 494.548

Synonyms:N-(tert-butoxycarbonyl)-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine methyl ester

Chemical Property of N-(tert-butoxycarbonyl)-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(tert-butoxycarbonyl)-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine methyl ester

There total 3 articles about N-(tert-butoxycarbonyl)-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

nitro-L-arginine methyl ester hydrochloride (51298-62-5) + (+/-)-N-(tert-butoxycarbonyl)-α-methylphenylalanine (86778-91-8) → N-(tert-butoxycarbonyl)-DL-α-methylphenylalanyl-Nω-nitro-L-arginine methyl ester (86778-92-9)

Guidance literature:

With N-Ethylmaleimide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; pH 7.0-7.5;

DOI:10.1021/jm00369a017

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → N-(tert-butoxycarbonyl)-DL-α-methylphenylalanyl-Nω-nitro-L-arginine methyl ester (86778-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / Et₃N / dimethylformamide / 18 h / 25 °C

2: 86 percent / HOBt, NEM, DCC / tetrahydrofuran / pH 7.0-7.5

With N-Ethylmaleimide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm00369a017

Reference yield:

2-methyl-3-phenylalanine (1132-26-9) → N-(tert-butoxycarbonyl)-DL-α-methylphenylalanyl-Nω-nitro-L-arginine methyl ester (86778-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / Et₃N / dimethylformamide / 18 h / 25 °C

2: 86 percent / HOBt, NEM, DCC / tetrahydrofuran / pH 7.0-7.5

With N-Ethylmaleimide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm00369a017

upstream raw materials:

nitro-L-arginine methyl ester hydrochloride

(+/-)-N-(tert-butoxycarbonyl)-α-methylphenylalanine

di-tert-butyl dicarbonate

2-methyl-3-phenylalanine

Downstream raw materials:

DL-α-methylphenylalanyl-N^ω-nitro-L-arginine methyl ester

N-(1-adamantylacetyl)-L-prolyl-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine methyl ester

N-(1-adamantylacetyl)-L-prolyl-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine

N-(5-phenylpentanoyl)-L-prolyl-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 86778-92-9 N-(tert-butoxycarbonyl)-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send