(2E)-3-(3,4-dimethoxy-5-nitrophenyl)-N'-[(1E)-(4-hydroxy-3-methoxy-5-nitrobenzylidene)]acrylohydrazide

Base Information

Chemical Name:(2E)-3-(3,4-dimethoxy-5-nitrophenyl)-N'-[(1E)-(4-hydroxy-3-methoxy-5-nitrobenzylidene)]acrylohydrazide
CAS No.:1394115-32-2
Molecular Formula:C₁₉H₁₈N₄O₉
Molecular Weight:446.373
Hs Code.:

Synonyms:(2E)-3-(3,4-dimethoxy-5-nitrophenyl)-N'-[(1E)-(4-hydroxy-3-methoxy-5-nitrobenzylidene)]acrylohydrazide

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Chemical Property of (2E)-3-(3,4-dimethoxy-5-nitrophenyl)-N'-[(1E)-(4-hydroxy-3-methoxy-5-nitrobenzylidene)]acrylohydrazide

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Technology Process of (2E)-3-(3,4-dimethoxy-5-nitrophenyl)-N'-[(1E)-(4-hydroxy-3-methoxy-5-nitrobenzylidene)]acrylohydrazide

There total 3 articles about (2E)-3-(3,4-dimethoxy-5-nitrophenyl)-N'-[(1E)-(4-hydroxy-3-methoxy-5-nitrobenzylidene)]acrylohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 6635-20-7
isonitrovanillin

: 1394115-40-2
(2E)-3-(3,4-dimethoxy-5-nitrophenyl)acrylohydrazide

: 1394115-32-2
(2E)-3-(3,4-dimethoxy-5-nitrophenyl)-N'-[(1E)-(4-hydroxy-3-methoxy-5-nitrobenzylidene)]acrylohydrazide

Guidance literature:: With hydrogenchloride; In ethanol; water; for 1h; Reflux;
DOI:10.1016/j.ejmech.2012.05.041

Reference yield:

: 949887-97-2
(2E)-3-(3,4-dimethoxy-5-nitrophenyl)acrylic acid

: 1394115-32-2
(2E)-3-(3,4-dimethoxy-5-nitrophenyl)-N'-[(1E)-(4-hydroxy-3-methoxy-5-nitrobenzylidene)]acrylohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 2 h / 20 °C

1.2: 0 - 10 °C

2.1: hydrogenchloride / ethanol; water / 1 h / Reflux

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; water; acetonitrile;
DOI:10.1016/j.ejmech.2012.05.041

Reference yield:

: 22027-96-9
5-nitroveratral

: 1394115-32-2
(2E)-3-(3,4-dimethoxy-5-nitrophenyl)-N'-[(1E)-(4-hydroxy-3-methoxy-5-nitrobenzylidene)]acrylohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1.1: piperidine; pyridine / 1 h / Reflux

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 2 h / 20 °C

2.2: 0 - 10 °C

3.1: hydrogenchloride / ethanol; water / 1 h / Reflux

With piperidine; pyridine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; water; acetonitrile; 1.1: Knoevenagel-Doebner reaction;
DOI:10.1016/j.ejmech.2012.05.041