4-amino-8-chloro-1-methyl-6-phenyl-6H-s-triazolo<4,3-a><1,4>benzodiazepine

Base Information

Chemical Name:4-amino-8-chloro-1-methyl-6-phenyl-6H-s-triazolo<4,3-a><1,4>benzodiazepine
CAS No.:41128-48-7
Molecular Formula:C₁₇H₁₄ClN₅
Molecular Weight:323.785
Hs Code.:

Synonyms:4-amino-8-chloro-1-methyl-6-phenyl-6H-s-triazolo<4,3-a><1,4>benzodiazepine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-amino-8-chloro-1-methyl-6-phenyl-6H-s-triazolo<4,3-a><1,4>benzodiazepine

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Technology Process of 4-amino-8-chloro-1-methyl-6-phenyl-6H-s-triazolo<4,3-a><1,4>benzodiazepine

There total 5 articles about 4-amino-8-chloro-1-methyl-6-phenyl-6H-s-triazolo<4,3-a><1,4>benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.2%

: 41128-47-6
4-amino-8-chloro-1-methyl-6-phenyl-4H-s-triazolo<4,3-a><1,4>benzodiazepine

: 41128-48-7
4-amino-8-chloro-1-methyl-6-phenyl-6H-s-triazolo<4,3-a><1,4>benzodiazepine

Guidance literature:: With sodium methylate; In methanol; for 7h; Ambient temperature;
DOI:10.1021/jm00180a012

Reference yield: 43.5%

: 41128-46-5
4-amino-8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine-4-carboxylic acid ethyl ester

: 41128-48-7
4-amino-8-chloro-1-methyl-6-phenyl-6H-s-triazolo<4,3-a><1,4>benzodiazepine

Guidance literature:: With sodium hydroxide; In ethanol; for 1.83333h; Ambient temperature;
DOI:10.1021/jm00180a012

Reference yield:

: 28981-97-7
alprazolam

: 41128-48-7
4-amino-8-chloro-1-methyl-6-phenyl-6H-s-triazolo<4,3-a><1,4>benzodiazepine

Guidance literature:: Multi-step reaction with 3 steps

1: 56 percent / NaH / ethanol / 1.5 h / Heating

2: 1.) NaH, 2.) O-(2,4-dinitrophenyl)hydroxylamine / 1.) DMF, RT, 1 h 50 min, 2.) DMF, 23 deg C, 2 h

3: 43.5 percent / 1N NaOH / ethanol / 1.83 h / Ambient temperature

With sodium hydroxide; sodium hydride; O-(2,4-dinitrophenyl)hydroxylamine; In ethanol;
DOI:10.1021/jm00180a012