C₁₇H₂₂BBrO₃

Base Information

• Chemical Name: C₁₇H₂₂BBrO₃
• CAS No.: 1400742-83-7
• Molecular Formula: C₁₇H₂₂BBrO₃
• Molecular Weight: 365.075
• Mol file: 1400742-83-7.mol

Synonyms:C₁₇H₂₂BBrO₃

Chemical Property of C₁₇H₂₂BBrO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₂₂BBrO₃

There total 3 articles about C₁₇H₂₂BBrO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

2,5-dibromostyrene (32917-57-0) + propargyl alcohol (107-19-7) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → C17H22BBrO3 (1400742-83-7) + C14H19BBr2O2 (1400742-84-8)

Guidance literature:

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; With potassium tert-butylate; copper(l) chloride; 1,2-bis-(dicyclohexylphosphino)ethane; In tetrahydrofuran; at 20 ℃; for 0.333333h; Glovebox; Inert atmosphere;

2,5-dibromostyrene; In tetrahydrofuran; at 40 ℃; for 18h; Inert atmosphere;

propargyl alcohol; With potassium carbonate; In tetrahydrofuran; at 45 ℃; Inert atmosphere;

DOI:10.1021/ja306446m

Reference yield:

1.4-dibromobenzene (106-37-6) → C17H22BBrO3 (1400742-83-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.83 h / -84 - 0 °C / Inert atmosphere

1.2: 3 h / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

2.2: 2.25 h / Inert atmosphere

3.1: potassium tert-butylate; copper(l) chloride; 1,2-bis-(dicyclohexylphosphino)ethane / tetrahydrofuran / 0.33 h / 20 °C / Glovebox; Inert atmosphere

3.2: 18 h / 40 °C / Inert atmosphere

3.3: 45 °C / Inert atmosphere

With n-butyllithium; potassium tert-butylate; copper(l) chloride; lithium diisopropyl amide; 1,2-bis-(dicyclohexylphosphino)ethane; In tetrahydrofuran; 2.1: |Wittig Olefination;

DOI:10.1021/ja306446m

Reference yield:

2,5-dibromobenzaldehyde (74553-29-0) → C17H22BBrO3 (1400742-83-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

1.2: 2.25 h / Inert atmosphere

2.1: potassium tert-butylate; copper(l) chloride; 1,2-bis-(dicyclohexylphosphino)ethane / tetrahydrofuran / 0.33 h / 20 °C / Glovebox; Inert atmosphere

2.2: 18 h / 40 °C / Inert atmosphere

2.3: 45 °C / Inert atmosphere

With n-butyllithium; potassium tert-butylate; copper(l) chloride; 1,2-bis-(dicyclohexylphosphino)ethane; In tetrahydrofuran; 1.1: |Wittig Olefination;

DOI:10.1021/ja306446m

upstream raw materials:

2,5-dibromostyrene

propargyl alcohol

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

1.4-dibromobenzene