(E)-5-(2-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)benzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

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Chemical Name:(E)-5-(2-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)benzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS No.:1311201-26-9
Molecular Formula:C₂₂H₃₂O₅Si
Molecular Weight:404.579
Hs Code.:

Synonyms:(E)-5-(2-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)benzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

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Chemical Property of (E)-5-(2-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)benzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

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Technology Process of (E)-5-(2-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)benzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

There total 4 articles about (E)-5-(2-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)benzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 2033-24-1
cycl-isopropylidene malonate

: 1311201-25-8
(E)-2-[3-(tert-butyldimethylsilyloxy)prop-1-en-yl]benzoic acid

: 1311201-26-9
(E)-5-(2-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)benzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

Guidance literature:: cycl-isopropylidene malonate; (E)-2-[3-(tert-butyldimethylsilyloxy)prop-1-en-yl]benzoic acid; With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 20h; Inert atmosphere;

With sodium tetrahydroborate; acetic acid; In dichloromethane; at 0 ℃; for 24h; Inert atmosphere;
DOI:10.1002/anie.201100772

Reference yield:

: 1311201-23-6
(E)-2-(3-hydroxyprop-1-enyl)benzaldehyde

: 1311201-26-9
(E)-5-(2-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)benzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / hexane; dichloromethane / 0.25 h / 0 °C / Inert atmosphere

2.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / water; tert-butyl alcohol / 8.17 h / 0 °C / Inert atmosphere

3.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 h / 0 °C / Inert atmosphere

3.2: 24 h / 0 °C / Inert atmosphere

With 1H-imidazole; dmap; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; dicyclohexyl-carbodiimide; In hexane; dichloromethane; water; tert-butyl alcohol;
DOI:10.1002/anie.201100772

Reference yield:

: 1311201-24-7
(E)-2-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)benzaldehyde

: 1311201-26-9
(E)-5-(2-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)benzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / water; tert-butyl alcohol / 8.17 h / 0 °C / Inert atmosphere

2.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 h / 0 °C / Inert atmosphere

2.2: 24 h / 0 °C / Inert atmosphere

With dmap; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; dicyclohexyl-carbodiimide; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1002/anie.201100772