tert-butyl 2-[4-amino-7-(benzyloxy)-2-(chloromethyl)-1H-imidazo[4,5-c]quinolin-1-yl]ethylcarbamate

Base Information

Chemical Name:tert-butyl 2-[4-amino-7-(benzyloxy)-2-(chloromethyl)-1H-imidazo[4,5-c]quinolin-1-yl]ethylcarbamate
CAS No.:852802-33-6
Molecular Formula:C₂₅H₂₈ClN₅O₃
Molecular Weight:481.982
Hs Code.:

Synonyms:tert-butyl 2-[4-amino-7-(benzyloxy)-2-(chloromethyl)-1H-imidazo[4,5-c]quinolin-1-yl]ethylcarbamate

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Chemical Property of tert-butyl 2-[4-amino-7-(benzyloxy)-2-(chloromethyl)-1H-imidazo[4,5-c]quinolin-1-yl]ethylcarbamate

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Technology Process of tert-butyl 2-[4-amino-7-(benzyloxy)-2-(chloromethyl)-1H-imidazo[4,5-c]quinolin-1-yl]ethylcarbamate

There total 9 articles about tert-butyl 2-[4-amino-7-(benzyloxy)-2-(chloromethyl)-1H-imidazo[4,5-c]quinolin-1-yl]ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₂₇ClN₄O₄

: 852802-33-6
tert-butyl 2-[4-amino-7-(benzyloxy)-2-(chloromethyl)-1H-imidazo[4,5-c]quinolin-1-yl]ethylcarbamate

Guidance literature:: C₂₅H₂₇ClN₄O₄; With ammonia; In chloroform; water; at 20 ℃; for 0.0333333h;

With p-toluenesulfonyl chloride; In chloroform; water; at 20 ℃; for 0.5h;

Reference yield:

: 749922-36-9
2-{[7-(benzyloxy)-3-nitroquinolin-4-yl]amino}ethanol

: 852802-33-6
tert-butyl 2-[4-amino-7-(benzyloxy)-2-(chloromethyl)-1H-imidazo[4,5-c]quinolin-1-yl]ethylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / N,N-dimethyl-formamide / 4 h / 20 °C

2.1: hydrogen / 5 % platinum on carbon / ethyl acetate / 1551.49 Torr

3.1: triethylamine / ethanol / 96 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 0.5 h / 20 °C

5.1: ammonia / chloroform; water / 0.03 h / 20 °C

5.2: 0.5 h / 20 °C

With ammonia; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid; 5 % platinum on carbon; In ethanol; chloroform; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 749922-33-6
5-{[(3-benzyloxy)phenylimino]methyl}-2,2-dimethyl-[1,3]-dioxane-4,6-dione

: 852802-33-6
tert-butyl 2-[4-amino-7-(benzyloxy)-2-(chloromethyl)-1H-imidazo[4,5-c]quinolin-1-yl]ethylcarbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: DOWTHERM A heat transfer fluid / 1.67 h / 100 - 210 °C

2.1: nitric acid / propionic acid / 1.5 h / 121 - 125 °C

3.1: trichlorophosphate / N,N-dimethyl-formamide / 0.08 h / 0 - 100 °C

4.1: triethylamine / N,N-dimethyl-formamide / 4 h / 20 °C

5.1: hydrogen / 5 % platinum on carbon / ethyl acetate / 1551.49 Torr

6.1: triethylamine / ethanol / 96 h / 20 °C

7.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 0.5 h / 20 °C

8.1: ammonia / chloroform; water / 0.03 h / 20 °C

8.2: 0.5 h / 20 °C

With ammonia; hydrogen; nitric acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; 5 % platinum on carbon; In DOWTHERM A heat transfer fluid; ethanol; chloroform; water; propionic acid; ethyl acetate; N,N-dimethyl-formamide;