ethyl 4-(4-fluorophenyl)-2-(methylsulfanyl)-6-(propan-2-yl)-1,4-dihydropyrimidine-5-carboxylate

Base Information

• Chemical Name: ethyl 4-(4-fluorophenyl)-2-(methylsulfanyl)-6-(propan-2-yl)-1,4-dihydropyrimidine-5-carboxylate
• CAS No.: 1619238-14-0
• Molecular Formula: C₁₇H₂₁FN₂O₂S
• Molecular Weight: 336.43
• Mol file: 1619238-14-0.mol

Synonyms:ethyl 4-(4-fluorophenyl)-2-(methylsulfanyl)-6-(propan-2-yl)-1,4-dihydropyrimidine-5-carboxylate

Chemical Property of ethyl 4-(4-fluorophenyl)-2-(methylsulfanyl)-6-(propan-2-yl)-1,4-dihydropyrimidine-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-(4-fluorophenyl)-2-(methylsulfanyl)-6-(propan-2-yl)-1,4-dihydropyrimidine-5-carboxylate

There total 4 articles about ethyl 4-(4-fluorophenyl)-2-(methylsulfanyl)-6-(propan-2-yl)-1,4-dihydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.2%

S-methylisothiourea hemisulphate (147895-43-0) + (E)-2-<(4-fluorophenyl)methylene>-4-methyl-3-oxopentanoic acid ethyl ester (122930-45-4) → ethyl 4-(4-fluorophenyl)-2-(methylsulfanyl)-6-(propan-2-yl)-1,4-dihydropyrimidine-5-carboxylate (1619238-14-0)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; at 100 ℃; for 22h; Inert atmosphere;

Reference yield:

ethyl 4-methyl-3-oxo-pentanoate (7152-15-0) → ethyl 4-(4-fluorophenyl)-2-(methylsulfanyl)-6-(propan-2-yl)-1,4-dihydropyrimidine-5-carboxylate (1619238-14-0)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine; acetic acid / isopropyl alcohol / 22 h / 20 °C / Inert atmosphere

2: N,N,N,N,N,N-hexamethylphosphoric triamide / 24 h / 100 °C

With piperidine; N,N,N,N,N,N-hexamethylphosphoric triamide; acetic acid; In isopropyl alcohol;

DOI:10.1039/c4gc00337c

Reference yield:

4-fluorobenzaldehyde (459-57-4) → ethyl 4-(4-fluorophenyl)-2-(methylsulfanyl)-6-(propan-2-yl)-1,4-dihydropyrimidine-5-carboxylate (1619238-14-0)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine; acetic acid / isopropyl alcohol / 22 h / 20 °C / Inert atmosphere

2: N,N,N,N,N,N-hexamethylphosphoric triamide / 24 h / 100 °C

With piperidine; N,N,N,N,N,N-hexamethylphosphoric triamide; acetic acid; In isopropyl alcohol;

DOI:10.1039/c4gc00337c

upstream raw materials:

ethyl 4-methyl-3-oxo-pentanoate

4-fluorobenzaldehyde

S-Methylisothiourea sulfate

(E)-2-<(4-fluorophenyl)methylene>-4-methyl-3-oxopentanoic acid ethyl ester

Downstream raw materials:

ethyl 4-(4-fluorophenyl)-2-(methylsulfanyl)-6-(propan-2-yl)-pyrimidine-5-carboxylate