tert-butyl (1-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)ethyl)carbamate

Base Information

Chemical Name:tert-butyl (1-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)ethyl)carbamate
CAS No.:1566544-45-3
Molecular Formula:C₁₈H₂₀ClF₃N₄O₂
Molecular Weight:416.831
Hs Code.:

Synonyms:tert-butyl (1-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)ethyl)carbamate

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Chemical Property of tert-butyl (1-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)ethyl)carbamate

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Technology Process of tert-butyl (1-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)ethyl)carbamate

There total 4 articles about tert-butyl (1-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 643086-68-4
[1-(4-amino-phenyl)-ethyl]carbamic acid tert-butyl ester

: 3932-97-6
2,4-dichloro-5-trifluoromethylpyrimidine

: 1566544-45-3
tert-butyl (1-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)ethyl)carbamate

Guidance literature:: 2,4-dichloro-5-trifluoromethylpyrimidine; With zinc(II) chloride; In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol; at 20 ℃; for 0.333333h;

[1-(4-amino-phenyl)-ethyl]carbamic acid tert-butyl ester; With triethylamine; In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol; at 20 ℃;

Reference yield:

: 100-19-6
(4-nitrophenyl)ethanone

: 1566544-45-3
tert-butyl (1-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium acetate / methanol / 0.33 h / 20 °C

1.2: 48 h

2.1: triethylamine / dichloromethane / 21 h / 20 °C

3.1: palladium; hydrogen / ethyl acetate / 3 h

4.1: zinc(II) chloride / tert-butyl alcohol; 1,2-dichloro-ethane; diethyl ether / 0.33 h / 20 °C

4.2: 20 °C

With ammonium acetate; hydrogen; palladium; triethylamine; zinc(II) chloride; In methanol; diethyl ether; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; tert-butyl alcohol;

Reference yield:

: 42142-15-4
1-(4-nitro-phenyl)-ethylamine

: 1566544-45-3
tert-butyl (1-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 21 h / 20 °C

2.1: palladium; hydrogen / ethyl acetate / 3 h

3.1: zinc(II) chloride / tert-butyl alcohol; 1,2-dichloro-ethane; diethyl ether / 0.33 h / 20 °C

3.2: 20 °C

With hydrogen; palladium; triethylamine; zinc(II) chloride; In diethyl ether; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; tert-butyl alcohol;