3-methyl-7-(6-phenylpyridin-3-yl)-5-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-3,4-dihydro-pyrazolo[1,5-a]pyrimido [5,4-e]pyrimidin-2(1H)-one

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Chemical Name:3-methyl-7-(6-phenylpyridin-3-yl)-5-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-3,4-dihydro-pyrazolo[1,5-a]pyrimido [5,4-e]pyrimidin-2(1H)-one
CAS No.:1361058-21-0
Molecular Formula:C₂₅H₂₄N₆O₃S
Molecular Weight:488.57
Hs Code.:

Synonyms:3-methyl-7-(6-phenylpyridin-3-yl)-5-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-3,4-dihydro-pyrazolo[1,5-a]pyrimido [5,4-e]pyrimidin-2(1H)-one

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Chemical Property of 3-methyl-7-(6-phenylpyridin-3-yl)-5-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-3,4-dihydro-pyrazolo[1,5-a]pyrimido [5,4-e]pyrimidin-2(1H)-one

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Technology Process of 3-methyl-7-(6-phenylpyridin-3-yl)-5-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-3,4-dihydro-pyrazolo[1,5-a]pyrimido [5,4-e]pyrimidin-2(1H)-one

There total 13 articles about 3-methyl-7-(6-phenylpyridin-3-yl)-5-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-3,4-dihydro-pyrazolo[1,5-a]pyrimido [5,4-e]pyrimidin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6-((methylamino)methyl)-3-(6-phenylpyridin-3-yl)-5-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)pyrazolo[1,5-a]pyrimidin-7-amine

: 530-62-1
1,1'-carbonyldiimidazole

: 1361058-21-0
3-methyl-7-(6-phenylpyridin-3-yl)-5-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-3,4-dihydro-pyrazolo[1,5-a]pyrimido [5,4-e]pyrimidin-2(1H)-one

Guidance literature:: With pyridine; at 20 ℃;

Reference yield:

: 128094-82-6
tetrahydro-thiopyran-4-carboxylic acid methyl ester

: 1361058-21-0
3-methyl-7-(6-phenylpyridin-3-yl)-5-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-3,4-dihydro-pyrazolo[1,5-a]pyrimido [5,4-e]pyrimidin-2(1H)-one

Guidance literature:: Multi-step reaction with 13 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

1.2: 3 h / -78 - -40 °C

2.1: acetic acid / 100 °C / sealed tube

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 45 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 20 °C

5.1: N-iodo-succinimide / acetonitrile / 1 h / 20 °C

6.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 90 °C / Inert atmosphere

7.1: N-Bromosuccinimide / acetonitrile / 0.5 h / 20 °C

8.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 1 h / 150 °C / microwave irradiation

9.1: 2,6-dimethylpyridine; sodium periodate / osmium(VIII) oxide / 1,4-dioxane; water / 96 h / 20 °C

10.1: sodium tetrahydroborate; methanol / 1 h / 20 °C

11.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 1 h / 0 - 20 °C

11.2: 20 °C

12.1: trifluoroacetic acid / water / 1 h

13.1: pyridine / 20 °C

With pyridine; 2,6-dimethylpyridine; methanol; sodium tetrahydroborate; potassium phosphate; sodium periodate; N-Bromosuccinimide; N-iodo-succinimide; n-butyllithium; acetic acid; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile;

Reference yield:

: 1260105-88-1
5-(tetrahydro-2H-thiopyran-4-yl)pyrazolo[1,5-a]pyrimidin-7-amine

: 1361058-21-0
3-methyl-7-(6-phenylpyridin-3-yl)-5-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-3,4-dihydro-pyrazolo[1,5-a]pyrimido [5,4-e]pyrimidin-2(1H)-one

Guidance literature:: Multi-step reaction with 11 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 45 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 20 °C

3.1: N-iodo-succinimide / acetonitrile / 1 h / 20 °C

4.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 90 °C / Inert atmosphere

5.1: N-Bromosuccinimide / acetonitrile / 0.5 h / 20 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 1 h / 150 °C / microwave irradiation

7.1: 2,6-dimethylpyridine; sodium periodate / osmium(VIII) oxide / 1,4-dioxane; water / 96 h / 20 °C

8.1: sodium tetrahydroborate; methanol / 1 h / 20 °C

9.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 1 h / 0 - 20 °C

9.2: 20 °C

10.1: trifluoroacetic acid / water / 1 h

11.1: pyridine / 20 °C

With pyridine; 2,6-dimethylpyridine; methanol; sodium tetrahydroborate; potassium phosphate; sodium periodate; N-Bromosuccinimide; N-iodo-succinimide; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile;