(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,2S)-2-benzyloxycarbonylamino-1-[1-(4-methoxy-benzyloxymethyl)-vinyl]-4-methyl-pentyl ester

Base Information

Chemical Name:(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,2S)-2-benzyloxycarbonylamino-1-[1-(4-methoxy-benzyloxymethyl)-vinyl]-4-methyl-pentyl ester
CAS No.:147298-43-9
Molecular Formula:C₃₅H₄₀F₃NO₇
Molecular Weight:643.7
Hs Code.:

(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,2S)-2-benzyloxycarbonylamino-1-[1-(4-methoxy-benzyloxymethyl)-vinyl]-4-methyl-pentyl ester

Synonyms:(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,2S)-2-benzyloxycarbonylamino-1-[1-(4-methoxy-benzyloxymethyl)-vinyl]-4-methyl-pentyl ester

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Chemical Property of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,2S)-2-benzyloxycarbonylamino-1-[1-(4-methoxy-benzyloxymethyl)-vinyl]-4-methyl-pentyl ester

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Technology Process of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,2S)-2-benzyloxycarbonylamino-1-[1-(4-methoxy-benzyloxymethyl)-vinyl]-4-methyl-pentyl ester

There total 2 articles about (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,2S)-2-benzyloxycarbonylamino-1-[1-(4-methoxy-benzyloxymethyl)-vinyl]-4-methyl-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 147298-43-9
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,2S)-2-benzyloxycarbonylamino-1-[1-(4-methoxy-benzyloxymethyl)-vinyl]-4-methyl-pentyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1) n-BuLi

With n-butyllithium;
DOI:10.1016/S0040-4039(00)77488-0

Reference yield:

: 70853-26-8,86852-22-4,71413-15-5
N-carbobenzoxy-L-leucinal

: 20445-33-4,39637-99-5
(R)-methoxytrifluoromethylphenylacetyl chloride

: 147298-36-0
1-(((2-bromoallyl)oxy)methyl)-4-methoxybenzene

: 147298-43-9
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,2S)-2-benzyloxycarbonylamino-1-[1-(4-methoxy-benzyloxymethyl)-vinyl]-4-methyl-pentyl ester

: (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,2S)-2-benzyloxycarbonylamino-1-[1-(4-methoxy-benzyloxymethyl)-vinyl]-4-methyl-pentyl ester

Guidance literature:: Yield given. Multistep reaction. Yields of byproduct given;
DOI:10.1016/S0040-4039(00)77488-0

Reference yield: 90.0%

: 147298-43-9
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,2S)-2-benzyloxycarbonylamino-1-[1-(4-methoxy-benzyloxymethyl)-vinyl]-4-methyl-pentyl ester

: 147298-40-6
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,2S)-2-benzyloxycarbonylamino-1-(1-hydroxymethyl-vinyl)-4-methyl-pentyl ester

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; for 16h; Ambient temperature;
DOI:10.1016/S0040-4039(00)77488-0