(N¹,N⁴,N⁹,N¹³-tetra-tert-butoxycarbonyl)-1,16-diamino-4,9,13-triazahexadecane

Base Information

• Chemical Name: (N¹,N⁴,N⁹,N¹³-tetra-tert-butoxycarbonyl)-1,16-diamino-4,9,13-triazahexadecane
• CAS No.: 128550-06-1
• Molecular Formula: C₃₃H₆₅N₅O₈
• Molecular Weight: 659.908
• Mol file: 128550-06-1.mol

Synonyms:(N¹,N⁴,N⁹,N¹³-tetra-tert-butoxycarbonyl)-1,16-diamino-4,9,13-triazahexadecane

Chemical Property of (N¹,N⁴,N⁹,N¹³-tetra-tert-butoxycarbonyl)-1,16-diamino-4,9,13-triazahexadecane

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (N¹,N⁴,N⁹,N¹³-tetra-tert-butoxycarbonyl)-1,16-diamino-4,9,13-triazahexadecane

There total 17 articles about (N¹,N⁴,N⁹,N¹³-tetra-tert-butoxycarbonyl)-1,16-diamino-4,9,13-triazahexadecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(3-Benzyloxycarbonylamino-propyl)-[3-(tert-butoxycarbonyl-{4-[tert-butoxycarbonyl-(3-tert-butoxycarbonylamino-propyl)-amino]-butyl}-amino)-propyl]-carbamic acid tert-butyl ester (196704-28-6) → (N1,N4,N9,N13-tetra-tert-butoxycarbonyl)-1,16-diamino-4,9,13-triazahexadecane (128550-06-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 6h;

DOI:10.1016/S0040-4020(97)00801-6

Reference yield: 88.0%

[3-(tert-butoxycarbonyl-{4-[tert-butoxycarbonyl-(3-tert-butoxycarbonylaminopropyl)-amino]-butyl}-amino)-propyl]-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamic acid tertiary-butyl ester (1208364-62-8) → (N1,N4,N9,N13-tetra-tert-butoxycarbonyl)-1,16-diamino-4,9,13-triazahexadecane (128550-06-1)

Guidance literature:

With hydrazine hydrate; In ethanol; for 6h; Reflux;

Reference yield: 71.0%

2-(2-cyanoethyl)-6,11-bis<(1,1-dimethylethoxy)carbonyl>-2,6,11,15-tetraazahexadecanedioic acid bis(1,1-dimethylethyl) ester (128550-05-0) → (N1,N4,N9,N13-tetra-tert-butoxycarbonyl)-1,16-diamino-4,9,13-triazahexadecane (128550-06-1)

Guidance literature:

With hydrogen; palladium dihydroxide; for 15h; under 2585.74 Torr;

DOI:10.1021/jm061198m

upstream raw materials:

2-(2-cyanoethyl)-6,11-bis<(1,1-dimethylethoxy)carbonyl>-2,6,11,15-tetraazahexadecanedioic acid bis(1,1-dimethylethyl) ester

(3-Benzyloxycarbonylamino-propyl)-[3-(tert-butoxycarbonyl-{4-[tert-butoxycarbonyl-(3-tert-butoxycarbonylamino-propyl)-amino]-butyl}-amino)-propyl]-carbamic acid tert-butyl ester

di-tert-butyl dicarbonate

tri-Boc-spermine

Downstream raw materials:

[3-({3-[bis-(2-cyano-ethyl)-amino]-propyl}-tert-butoxycarbonyl-amino)-propyl]-{4-[tert-butoxycarbonyl-(3-tert-butoxycarbonylamino-propyl)-amino]-butyl}-carbamic acid tert-butyl ester

[3-(tert-Butoxycarbonyl-{4-[tert-butoxycarbonyl-(3-tert-butoxycarbonylamino-propyl)-amino]-butyl}-amino)-propyl]-[3-(2-cyano-ethylamino)-propyl]-carbamic acid tert-butyl ester

1-<4-(methoxymethoxy)phenyl>-26,26-dimethyl-1,24-dioxo-25-oxa-2,6,10,14,19,23-hexaazaheptacosane-10,14,19-tricarboxylic acid tris(1,1-dimethylethyl) ester

1-<4-(methoxymethoxy)phenyl>-6-hydroxy-26,26-dimethyl-1,24-dioxo-25-oxa-2,6,10,14,19,23-hexaazaheptacosane-10,14,19-tricarboxylic acid tris(1,1-dimethylethyl) ester