(1R,2R)-1-{(4R,5R)-5-[(R)-4-(tert-Butyl-diphenyl-silanyloxy)-1-methoxy-butyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-methyl-but-3-en-1-ol

Base Information

Chemical Name:(1R,2R)-1-{(4R,5R)-5-[(R)-4-(tert-Butyl-diphenyl-silanyloxy)-1-methoxy-butyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-methyl-but-3-en-1-ol
CAS No.:913343-99-4
Molecular Formula:C₃₁H₄₆O₅Si
Molecular Weight:526.789
Hs Code.:

Synonyms:(1R,2R)-1-{(4R,5R)-5-[(R)-4-(tert-Butyl-diphenyl-silanyloxy)-1-methoxy-butyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-methyl-but-3-en-1-ol

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Chemical Property of (1R,2R)-1-{(4R,5R)-5-[(R)-4-(tert-Butyl-diphenyl-silanyloxy)-1-methoxy-butyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-methyl-but-3-en-1-ol

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Technology Process of (1R,2R)-1-{(4R,5R)-5-[(R)-4-(tert-Butyl-diphenyl-silanyloxy)-1-methoxy-butyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-methyl-but-3-en-1-ol

There total 7 articles about (1R,2R)-1-{(4R,5R)-5-[(R)-4-(tert-Butyl-diphenyl-silanyloxy)-1-methoxy-butyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-methyl-but-3-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-Butyl-[(4S,5R)-5-((R)-1-methoxy-but-3-enyl)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy]-dimethyl-silane

: 913343-99-4
(1R,2R)-1-{(4R,5R)-5-[(R)-4-(tert-Butyl-diphenyl-silanyloxy)-1-methoxy-butyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-methyl-but-3-en-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: BH₃*THF / tetrahydrofuran

1.2: H₂O₂ / tetrahydrofuran

2.1: imidazole / CH₂Cl₂

3.1: camphorsulfonic acid / methanol

4.1: pyridine*SO₃; dimethyl sulfoxide; triethylamine / CH₂Cl₂

5.1: tetrahydrofuran / -78 °C

With 1H-imidazole; borane-THF; camphor-10-sulfonic acid; sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/anie.200601654

Reference yield:

: (R)-4-[(4R,5S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-4-methoxy-butan-1-ol

: 913343-99-4
(1R,2R)-1-{(4R,5R)-5-[(R)-4-(tert-Butyl-diphenyl-silanyloxy)-1-methoxy-butyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-methyl-but-3-en-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / CH₂Cl₂

2: camphorsulfonic acid / methanol

3: pyridine*SO₃; dimethyl sulfoxide; triethylamine / CH₂Cl₂

4: tetrahydrofuran / -78 °C

With 1H-imidazole; camphor-10-sulfonic acid; sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/anie.200601654

Reference yield:

: {(4S,5R)-5-[(R)-4-(tert-Butyl-diphenyl-silanyloxy)-1-methoxy-butyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-methanol

: 913343-99-4
(1R,2R)-1-{(4R,5R)-5-[(R)-4-(tert-Butyl-diphenyl-silanyloxy)-1-methoxy-butyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-methyl-but-3-en-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine*SO₃; dimethyl sulfoxide; triethylamine / CH₂Cl₂

2: tetrahydrofuran / -78 °C

With sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.200601654