HCl*bis[Lys(4-[1-{1-tert-butyl-3,3,5,5-tetraethylpiperazin-2-on-1-yloxy}ethyl]benzoyl)-Gly]-OMe

Base Information

• Chemical Name: HCl*bis[Lys(4-[1-{1-tert-butyl-3,3,5,5-tetraethylpiperazin-2-on-1-yloxy}ethyl]benzoyl)-Gly]-OMe
• CAS No.: 1295579-08-6
• Molecular Formula: C₆₇H₁₁₀N₁₀O₁₁*ClH
• Molecular Weight: 1268.13
• Mol file: 1295579-08-6.mol

Synonyms:HCl*bis[Lys(4-[1-{1-tert-butyl-3,3,5,5-tetraethylpiperazin-2-on-1-yloxy}ethyl]benzoyl)-Gly]-OMe

Chemical Property of HCl*bis[Lys(4-[1-{1-tert-butyl-3,3,5,5-tetraethylpiperazin-2-on-1-yloxy}ethyl]benzoyl)-Gly]-OMe

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of HCl*bis[Lys(4-[1-{1-tert-butyl-3,3,5,5-tetraethylpiperazin-2-on-1-yloxy}ethyl]benzoyl)-Gly]-OMe

There total 14 articles about HCl*bis[Lys(4-[1-{1-tert-butyl-3,3,5,5-tetraethylpiperazin-2-on-1-yloxy}ethyl]benzoyl)-Gly]-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Boc-bis[Lys(4-[1-{1-tert-butyl-3,3,5,5-tetraethylpiperazin-2-on-1-yloxy}ethyl]benzoyl)-Gly]-OMe (1295578-96-9) → HCl*bis[Lys(4-[1-{1-tert-butyl-3,3,5,5-tetraethylpiperazin-2-on-1-yloxy}ethyl]benzoyl)-Gly]-OMe (1295579-08-6)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1039/c0ob01047b

Reference yield:

1-tert-butyl-3,3,5,5-tetraethyl-2-piperazinone (264280-20-8) → HCl*bis[Lys(4-[1-{1-tert-butyl-3,3,5,5-tetraethylpiperazin-2-on-1-yloxy}ethyl]benzoyl)-Gly]-OMe (1295579-08-6)

Guidance literature:

Multi-step reaction with 7 steps

1.1: peracetic acid; acetic acid / ethyl acetate / 16 h / 0 - 20 °C / Inert atmosphere

2.1: Cu(OTf)2; copper; 4,4'-di-tert-butyl-2,2'-bipyridine / benzene / 16 h / 75 °C / Inert atmosphere

3.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.33 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C

3.3: 20 °C

4.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C / Inert atmosphere

5.1: sodium hydroxide / methanol; water / 18 h / 20 °C / Inert atmosphere

5.2: 20 °C / Inert atmosphere

6.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C / Inert atmosphere

7.1: hydrogenchloride / methanol / 16 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; peracetic acid; Cu(OTf)2; tert.-butyl lithium; copper; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4,4'-di-tert-butyl-2,2'-bipyridine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; pentane; benzene;

DOI:10.1039/c0ob01047b

Reference yield:

3-nitropentane (551-88-2) → HCl*bis[Lys(4-[1-{1-tert-butyl-3,3,5,5-tetraethylpiperazin-2-on-1-yloxy}ethyl]benzoyl)-Gly]-OMe (1295579-08-6)

Guidance literature:

Multi-step reaction with 10 steps

1.1: water / 318 h / 0 - 20 °C

2.1: acetic acid; zinc / water / 2 h / 20 °C / Cooling with ice

3.1: potassium hydroxide / 18 h / 10 - 20 °C

4.1: peracetic acid; acetic acid / ethyl acetate / 16 h / 0 - 20 °C / Inert atmosphere

5.1: Cu(OTf)2; copper; 4,4'-di-tert-butyl-2,2'-bipyridine / benzene / 16 h / 75 °C / Inert atmosphere

6.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.33 h / -78 °C / Inert atmosphere

6.2: -78 - 20 °C

6.3: 20 °C

7.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C / Inert atmosphere

8.1: sodium hydroxide / methanol; water / 18 h / 20 °C / Inert atmosphere

8.2: 20 °C / Inert atmosphere

9.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C / Inert atmosphere

10.1: hydrogenchloride / methanol / 16 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; peracetic acid; Cu(OTf)2; tert.-butyl lithium; copper; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4,4'-di-tert-butyl-2,2'-bipyridine; potassium hydroxide; sodium hydroxide; zinc; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; pentane; benzene;

DOI:10.1039/c0ob01047b

upstream raw materials:

Boc-Lys-Gly-OMe*HCl

N-tert-butyl-(2-ethyl-2-nitrobutyl)-amine

N-tert-butyl-2-ethylbutane-1,2-diamine

1-tert-butyl-3,3,5,5-tetraethyl-2-piperazinone

Downstream raw materials:

Boc-tetrakis[Lys(4-[1-{1-tert-butyl-3,3,5,5-tetraethylpiperazin-2-on-1-yloxy}ethyl]benzoyl)-Gly]-OMe