Trifluoro-methanesulfonic acid 9-benzyl-1-oxo-3-phenyl-2-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-2,9-dihydro-1H-β-carbolin-8-yl ester

Base Information

Chemical Name:Trifluoro-methanesulfonic acid 9-benzyl-1-oxo-3-phenyl-2-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-2,9-dihydro-1H-β-carbolin-8-yl ester
CAS No.:1027427-93-5
Molecular Formula:C₃₃H₂₉F₆N₃O₆S
Molecular Weight:709.666
Hs Code.:

Trifluoro-methanesulfonic acid 9-benzyl-1-oxo-3-phenyl-2-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-2,9-dihydro-1H-β-carbolin-8-yl ester

Synonyms:Trifluoro-methanesulfonic acid 9-benzyl-1-oxo-3-phenyl-2-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-2,9-dihydro-1H-β-carbolin-8-yl ester

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Chemical Property of Trifluoro-methanesulfonic acid 9-benzyl-1-oxo-3-phenyl-2-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-2,9-dihydro-1H-β-carbolin-8-yl ester

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Technology Process of Trifluoro-methanesulfonic acid 9-benzyl-1-oxo-3-phenyl-2-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-2,9-dihydro-1H-β-carbolin-8-yl ester

There total 12 articles about Trifluoro-methanesulfonic acid 9-benzyl-1-oxo-3-phenyl-2-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-2,9-dihydro-1H-β-carbolin-8-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 106746-09-2
3(RS)-amino-1,1,1-trifluoro-2(RS)-hydroxy-4-methylpentane hydrochloride

: 1027427-93-5
Trifluoro-methanesulfonic acid 9-benzyl-1-oxo-3-phenyl-2-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-2,9-dihydro-1H-β-carbolin-8-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1-hydroxybenzotriazole, triethylamine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodimide / dimethylformamide

2: 1.18 g / triethylamine / CH₂Cl₂ / 12 h

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00001a014

Reference yield:

: (8,9-Dibenzyl-1-oxo-3-phenyl-1,9-dihydro-β-carbolin-2-yl)-acetic acid

: 1027427-93-5
Trifluoro-methanesulfonic acid 9-benzyl-1-oxo-3-phenyl-2-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-2,9-dihydro-1H-β-carbolin-8-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: EDC, Et₃N / dimethylformamide

2: 1.6 g / H₂ / 10percent Pd/C / ethanol

3: 1.18 g / triethylamine / CH₂Cl₂ / 12 h

With hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00001a014

Reference yield:

: 1026076-48-1
2-(9-Benzyl-8-benzyloxy-1-oxo-3-phenyl-1,9-dihydro-β-carbolin-2-yl)-N-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propyl)-acetamide

: 1027427-93-5
Trifluoro-methanesulfonic acid 9-benzyl-1-oxo-3-phenyl-2-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-2,9-dihydro-1H-β-carbolin-8-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.6 g / H₂ / 10percent Pd/C / ethanol

2: 1.18 g / triethylamine / CH₂Cl₂ / 12 h

With hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm00001a014