N-((3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)sulfonyl)propionamide

Base Information

Chemical Name:N-((3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)sulfonyl)propionamide
CAS No.:1445879-60-6
Molecular Formula:C₂₇H₂₈N₆O₇S₂
Molecular Weight:612.687
Hs Code.:

Synonyms:N-((3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)sulfonyl)propionamide

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Chemical Property of N-((3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)sulfonyl)propionamide

Chemical Property:

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Technology Process of N-((3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)sulfonyl)propionamide

There total 7 articles about N-((3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)sulfonyl)propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1319719-21-5
N-(3-aminophenylsulfonyl)propionamide

: 1445880-62-5
4-chloro-N-cyclopropyl-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-sulfonamide

: 1445879-60-6
N-((3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)sulfonyl)propionamide

Guidance literature:: In 1,4-dioxane; ethanol; at 90 ℃; for 4h;

Reference yield:

: 82121-06-0
4-hydroxy-7-bromoquinoline

: 1445879-60-6
N-((3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)sulfonyl)propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: chlorosulfonic acid / 18 h / 100 °C

2: trichlorophosphate / 3 h / Reflux

3: triethylamine / dichloromethane / 1 h / 0 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 1 h / 80 °C

5: 1,4-dioxane; ethanol / 4 h / 90 °C

With chlorosulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triethylamine; trichlorophosphate; In 1,4-dioxane; ethanol; dichloromethane; water;

Reference yield:

: 13604-94-9
N-(3-nitrophenylsulfonyl)propionamide

: 1445879-60-6
N-((3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)sulfonyl)propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C

2: 1,4-dioxane; ethanol / 4 h / 90 °C

With palladium 10% on activated carbon; hydrogen; In 1,4-dioxane; methanol; ethanol;