2-chloro-N-{1'-[(E)-3-(4-chloro-phenyl)-allyl]-6-trifluoromethyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl-3-yl}-isonicotinamide N-oxide

Base Information

Chemical Name:2-chloro-N-{1'-[(E)-3-(4-chloro-phenyl)-allyl]-6-trifluoromethyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl-3-yl}-isonicotinamide N-oxide
CAS No.:1196844-72-0
Molecular Formula:C₂₆H₂₃Cl₂F₃N₄O₂
Molecular Weight:551.395
Hs Code.:

Synonyms:2-chloro-N-{1'-[(E)-3-(4-chloro-phenyl)-allyl]-6-trifluoromethyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl-3-yl}-isonicotinamide N-oxide

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Chemical Property of 2-chloro-N-{1'-[(E)-3-(4-chloro-phenyl)-allyl]-6-trifluoromethyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl-3-yl}-isonicotinamide N-oxide

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Technology Process of 2-chloro-N-{1'-[(E)-3-(4-chloro-phenyl)-allyl]-6-trifluoromethyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl-3-yl}-isonicotinamide N-oxide

There total 8 articles about 2-chloro-N-{1'-[(E)-3-(4-chloro-phenyl)-allyl]-6-trifluoromethyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl-3-yl}-isonicotinamide N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1196696-57-7
2-chloro-N-{1'-[(E)-3-(4-chloro-phenyl)-allyl]-6-trifluoromethyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl-3-yl}-isonicotinamide

: 1196844-72-0
2-chloro-N-{1'-[(E)-3-(4-chloro-phenyl)-allyl]-6-trifluoromethyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl-3-yl}-isonicotinamide N-oxide

Guidance literature:: With dihydrogen peroxide; In methanol; water; at 50 ℃; for 20h;

Reference yield:

: 1196698-19-7
3-amino-6-trifluoromethyl-3',6'-dihydro-2'H-[2,4']bipyridinyl-1'-carboxylic acid tert-butyl ester

: 1196844-72-0
2-chloro-N-{1'-[(E)-3-(4-chloro-phenyl)-allyl]-6-trifluoromethyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl-3-yl}-isonicotinamide N-oxide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 48 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / toluene / 2 h / 20 °C

2.2: Saturated solution

3.1: dichloromethane / 1 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 20 °C

5.1: dihydrogen peroxide / methanol; water / 20 h / 50 °C

With hydrogen; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1196844-72-0
2-chloro-N-{1'-[(E)-3-(4-chloro-phenyl)-allyl]-6-trifluoromethyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl-3-yl}-isonicotinamide N-oxide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3 h / 80 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 48 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / toluene / 2 h / 20 °C

3.2: Saturated solution

4.1: dichloromethane / 1 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 20 °C

6.1: dihydrogen peroxide / methanol; water / 20 h / 50 °C

With potassium phosphate; hydrogen; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; toluene; acetonitrile;