7-amino-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-2-(furan-2-yl)thieno[2,3-b]pyrazine-6-carboxamide

Base Information

Chemical Name:7-amino-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-2-(furan-2-yl)thieno[2,3-b]pyrazine-6-carboxamide
CAS No.:1351237-65-4
Molecular Formula:C₂₉H₂₄N₆O₃S
Molecular Weight:536.614
Hs Code.:

Synonyms:7-amino-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-2-(furan-2-yl)thieno[2,3-b]pyrazine-6-carboxamide

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Chemical Property of 7-amino-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-2-(furan-2-yl)thieno[2,3-b]pyrazine-6-carboxamide

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Technology Process of 7-amino-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-2-(furan-2-yl)thieno[2,3-b]pyrazine-6-carboxamide

There total 12 articles about 7-amino-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-2-(furan-2-yl)thieno[2,3-b]pyrazine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1351238-42-0
7-amino-2-(furan-2-yl)thieno[2,3-b]pyrazine-6-carboxylic acid

: 1351238-05-5
N-(3-amino-4-methylphenyl)-3-(2-cyanopropan-2-yl)benzamide hydrochloride

: 1351237-65-4
7-amino-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-2-(furan-2-yl)thieno[2,3-b]pyrazine-6-carboxamide

Guidance literature:: 7-amino-2-(furan-2-yl)thieno[2,3-b]pyrazine-6-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 0.5h;

N-(3-amino-4-methylphenyl)-3-(2-cyanopropan-2-yl)benzamide hydrochloride; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield: 34.0%

: 1351238-42-0
7-amino-2-(furan-2-yl)thieno[2,3-b]pyrazine-6-carboxylic acid

: N-(3-amino-4-methylphenyl)-3-(2-cyanopropan-2-yl)benzamide hydrochloride

: 1351237-65-4
7-amino-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-2-(furan-2-yl)thieno[2,3-b]pyrazine-6-carboxamide

Guidance literature:: 7-amino-2-(furan-2-yl)thieno[2,3-b]pyrazine-6-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

N-(3-amino-4-methylphenyl)-3-(2-cyanopropan-2-yl)benzamide hydrochloride; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield:

: 615-09-8
ethyl 3-(2-furyl)-3-oxopropanoate

: 1351237-65-4
7-amino-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-2-(furan-2-yl)thieno[2,3-b]pyrazine-6-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydroxide / water / 20 °C

1.2: 0.25 h / 0 °C

2.1: isopropyl alcohol / 70 h / 20 °C

3.1: triethyl phosphite / 1.33 h / 130 °C

4.1: copper(ll) bromide; tert.-butylnitrite / N,N-dimethyl-formamide / 0.83 h / 55 °C

5.1: sodium carbonate / ethanol / 3 h / 20 - 50 °C

6.1: potassium hydroxide; water / ethanol / 1 h / 70 °C

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h

7.2: 80 °C

With tert.-butylnitrite; water; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; copper(ll) bromide; triethyl phosphite; In ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; 4.1: Sandmeyer Reaction;