Technology Process of (+/-)-methyl 3-(4-(4-methyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)pentan-2-yl)benzamido)propanoate
There total 7 articles about (+/-)-methyl 3-(4-(4-methyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)pentan-2-yl)benzamido)propanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium 10% on activated carbon;
In
methanol;
at 50 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: tetrahydrofuran / 0 - 20 °C
2.1: pyridinium chlorochromate / dichloromethane / 48 h / 0 - 20 °C
3.1: lithium hexamethyldisilazane / toluene / 1 h / 0 - 20 °C
3.2: 18 h
4.1: potassium carbonate / copper(l) iodide; 8-quinolinol / dimethyl sulfoxide / 18 h / 90 °C / Inert atmosphere
5.1: sodium hydroxide; methanol / tetrahydrofuran / 60 h / 20 °C
5.2: pH 2
6.1: 1-hydroxy-7-aza-benzotriazole; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C
7.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 50 °C
With
methanol; 1-hydroxy-7-aza-benzotriazole; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; pyridinium chlorochromate; sodium hydroxide; lithium hexamethyldisilazane;
copper(l) iodide; 8-quinolinol; palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene;
1.1: Grignard Reaction;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium hexamethyldisilazane / toluene / 1 h / 0 - 20 °C
1.2: 18 h
2.1: potassium carbonate / copper(l) iodide; 8-quinolinol / dimethyl sulfoxide / 18 h / 90 °C / Inert atmosphere
3.1: sodium hydroxide; methanol / tetrahydrofuran / 60 h / 20 °C
3.2: pH 2
4.1: 1-hydroxy-7-aza-benzotriazole; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C
5.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 50 °C
With
methanol; 1-hydroxy-7-aza-benzotriazole; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; lithium hexamethyldisilazane;
copper(l) iodide; 8-quinolinol; palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene;
