3-[(4-methylphenyl)amino]-N-[(phenylcarbamothioyl)-amino]propanamide

Base Information

• Chemical Name: 3-[(4-methylphenyl)amino]-N-[(phenylcarbamothioyl)-amino]propanamide
• CAS No.: 1410133-64-0
• Molecular Formula: C₁₇H₂₀N₄OS
• Molecular Weight: 328.438
• Mol file: 1410133-64-0.mol

Synonyms:3-[(4-methylphenyl)amino]-N-[(phenylcarbamothioyl)-amino]propanamide

Chemical Property of 3-[(4-methylphenyl)amino]-N-[(phenylcarbamothioyl)-amino]propanamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-[(4-methylphenyl)amino]-N-[(phenylcarbamothioyl)-amino]propanamide

There total 2 articles about 3-[(4-methylphenyl)amino]-N-[(phenylcarbamothioyl)-amino]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

3-[(4-methylphenyl)amino]propanehydrazide (21911-86-4) + phenyl isothiocyanate (103-72-0) → 3-[(4-methylphenyl)amino]-N-[(phenylcarbamothioyl)-amino]propanamide (1410133-64-0)

Guidance literature:

In methanol; for 1.5h; Reflux;

DOI:10.1007/s00706-012-0799-0

Reference yield:

3-(p-methylphenylamino)propanoic acid (27418-59-3) → 3-[(4-methylphenyl)amino]-N-[(phenylcarbamothioyl)-amino]propanamide (1410133-64-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine / toluene / Reflux

2: methanol / 1.5 h / Reflux

With hydrazine; In methanol; toluene;

DOI:10.1007/s00706-012-0799-0

Reference yield: 94.0%

3-[(4-methylphenyl)amino]-N-[(phenylcarbamothioyl)-amino]propanamide (1410133-64-0) → 5-[2-[(4-methylphenyl)amino]ethyl]-N-phenyl-1,3,4-thiadiazol-2-amine (1410133-99-1)

Guidance literature:

With sulfuric acid; at 20 ℃; Cooling with ice;

DOI:10.1007/s00706-012-0799-0

upstream raw materials:

3-[(4-methylphenyl)amino]propanehydrazide

phenyl isothiocyanate

3-(p-methylphenylamino)propanoic acid

Downstream raw materials:

N-(3,4-diphenyl-2(3H)-thiazolylidene)-3-[(4-methylphenyl)amino]propanehydrazide

2,4-dihydro-5-[2-[(4-methylphenyl)amino]ethyl]-4-phenyl-3H-1,2,4-triazole-3-thione

5-[2-[(4-methylphenyl)amino]ethyl]-N-phenyl-1,3,4-thiadiazol-2-amine