3-(2-Hydroxycarbamoylmethyl-3-phenyl-propionylamino)-2-methyl-propionic acid

Base Information

Chemical Name:3-(2-Hydroxycarbamoylmethyl-3-phenyl-propionylamino)-2-methyl-propionic acid
CAS No.:120377-49-3
Molecular Formula:C₁₅H₂₀N₂O₅
Molecular Weight:308.334
Hs Code.:

Synonyms:3-(2-Hydroxycarbamoylmethyl-3-phenyl-propionylamino)-2-methyl-propionic acid

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Chemical Property of 3-(2-Hydroxycarbamoylmethyl-3-phenyl-propionylamino)-2-methyl-propionic acid

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Technology Process of 3-(2-Hydroxycarbamoylmethyl-3-phenyl-propionylamino)-2-methyl-propionic acid

There total 5 articles about 3-(2-Hydroxycarbamoylmethyl-3-phenyl-propionylamino)-2-methyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.6%

: 120686-49-9
3-[(E)-2-(Benzyloxycarbamoyl-methyl)-3-phenyl-acryloylamino]-2-methyl-propionic acid

: 120377-49-3
3-(2-Hydroxycarbamoylmethyl-3-phenyl-propionylamino)-2-methyl-propionic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 5h; Ambient temperature;
DOI:10.1021/jm00127a017

Reference yield:

: 87439-00-7
3-(ethoxycarbonyl)-2-benzylidenepropanoic acid

: 120377-49-3
3-(2-Hydroxycarbamoylmethyl-3-phenyl-propionylamino)-2-methyl-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / tetrahydrofuran; CHCl₃ / 1.) 0 deg C, 1 h, 2.) r.t., overnight

2: 92.4 percent / 1 M NaOH / ethanol; H₂O / 1.) 0 deg C, 1 h, 2.) r.t., 5 h

3: 22.4 percent / triethylamine, 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / tetrahydrofuran; CHCl₃ / 1.) 0 deg C, 1 h, 2.) r.t., overnight

4: 43.4 percent / trifluoroacetic acid / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) 4 deg C, overnight

5: 53.6 percent / hydrogen / 10 percent Pd/charcoal / methanol / 5 h / Ambient temperature

With sodium hydroxide; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water;
DOI:10.1021/jm00127a017

Reference yield:

: 120686-32-0
(E)-3-(2-tert-Butoxycarbonyl-propylcarbamoyl)-4-phenyl-but-3-enoic acid

: 120377-49-3
3-(2-Hydroxycarbamoylmethyl-3-phenyl-propionylamino)-2-methyl-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 22.4 percent / triethylamine, 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / tetrahydrofuran; CHCl₃ / 1.) 0 deg C, 1 h, 2.) r.t., overnight

2: 43.4 percent / trifluoroacetic acid / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) 4 deg C, overnight

3: 53.6 percent / hydrogen / 10 percent Pd/charcoal / methanol / 5 h / Ambient temperature

With hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; chloroform;
DOI:10.1021/jm00127a017