(R)-4-((S)-1-Hydroxy-hept-2-ynyl)-2,2-dimethyl-thiazolidine-3-carboxylic acid benzylamide

Base Information

Chemical Name:(R)-4-((S)-1-Hydroxy-hept-2-ynyl)-2,2-dimethyl-thiazolidine-3-carboxylic acid benzylamide
CAS No.:159114-05-3
Molecular Formula:C₂₀H₂₈N₂O₂S
Molecular Weight:360.521
Hs Code.:

Synonyms:(R)-4-((S)-1-Hydroxy-hept-2-ynyl)-2,2-dimethyl-thiazolidine-3-carboxylic acid benzylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-((S)-1-Hydroxy-hept-2-ynyl)-2,2-dimethyl-thiazolidine-3-carboxylic acid benzylamide

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Technology Process of (R)-4-((S)-1-Hydroxy-hept-2-ynyl)-2,2-dimethyl-thiazolidine-3-carboxylic acid benzylamide

There total 4 articles about (R)-4-((S)-1-Hydroxy-hept-2-ynyl)-2,2-dimethyl-thiazolidine-3-carboxylic acid benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 3173-56-6
benzyl isothiocyanate

: 159114-04-2
(S)-1-((R)-2,2-Dimethyl-thiazolidin-4-yl)-hept-2-yn-1-ol

: 159114-05-3
(R)-4-((S)-1-Hydroxy-hept-2-ynyl)-2,2-dimethyl-thiazolidine-3-carboxylic acid benzylamide

Guidance literature:: With pyridine; for 12h; Ambient temperature;
DOI:10.1021/jo00099a009

Reference yield:

: 133228-61-2
tert-butyl (4R)-4-formyl-2,2-dimethylthiazolidine-3-carboxylate

: 159114-05-3
(R)-4-((S)-1-Hydroxy-hept-2-ynyl)-2,2-dimethyl-thiazolidine-3-carboxylic acid benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1: n-BuLi, HMPA / tetrahydrofuran / 12 h / -78 °C

2: 71 percent / p-TsOH / methanol / 11 h / 35 °C

3: 99 percent / pyridine / 12 h / Ambient temperature

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; toluene-4-sulfonic acid; In tetrahydrofuran; methanol;
DOI:10.1021/jo00099a009

Reference yield:

: 693-02-7
hex-1-yne

: 159114-05-3
(R)-4-((S)-1-Hydroxy-hept-2-ynyl)-2,2-dimethyl-thiazolidine-3-carboxylic acid benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1: n-BuLi, HMPA / tetrahydrofuran / 12 h / -78 °C

2: 71 percent / p-TsOH / methanol / 11 h / 35 °C

3: 99 percent / pyridine / 12 h / Ambient temperature

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; toluene-4-sulfonic acid; In tetrahydrofuran; methanol;
DOI:10.1021/jo00099a009