8-chloro-6-(2-chlorophenyl)-1H,4H-pyrrolo<3,2-d><2>benzazepine-2-carboxamide

Base Information

Chemical Name:8-chloro-6-(2-chlorophenyl)-1H,4H-pyrrolo<3,2-d><2>benzazepine-2-carboxamide
CAS No.:126802-78-6
Molecular Formula:C₁₉H₁₃Cl₂N₃O
Molecular Weight:370.238
Hs Code.:

Synonyms:8-chloro-6-(2-chlorophenyl)-1H,4H-pyrrolo<3,2-d><2>benzazepine-2-carboxamide

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Chemical Property of 8-chloro-6-(2-chlorophenyl)-1H,4H-pyrrolo<3,2-d><2>benzazepine-2-carboxamide

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Technology Process of 8-chloro-6-(2-chlorophenyl)-1H,4H-pyrrolo<3,2-d><2>benzazepine-2-carboxamide

There total 4 articles about 8-chloro-6-(2-chlorophenyl)-1H,4H-pyrrolo<3,2-d><2>benzazepine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 126802-77-5
8-chloro-6-(2-chlorophenyl)-1H,4H-pyrrolo<3,2-d><2>benzazepine-2-carboxylic acid ethyl ester

: 126802-78-6
8-chloro-6-(2-chlorophenyl)-1H,4H-pyrrolo<3,2-d><2>benzazepine-2-carboxamide

Guidance literature:: With ammonium chloride; ammonia; In methanol; at 100 ℃; for 72h;

Reference yield:

: 58582-31-3
8-chloro-1-(2-chlorophenyl)-4-dimethylaminomethylene-3,4-dihydro-2-benzazepin-5-one

: 126802-78-6
8-chloro-6-(2-chlorophenyl)-1H,4H-pyrrolo<3,2-d><2>benzazepine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 58 percent / potassium t-butoxide / tetrahydrofuran / 1 h / 5 - 8 °C

2: 42 percent / conc. sulfuric acid / ethanol / 0.08 h / Heating

3: 3.5 g / sodium hydroxyde, water / methanol / 4.5 h / Heating

4: 0.75 g / phosphorus pentachloride, ammonia gas / CH₂Cl₂ / 1 h / Ambient temperature

With sodium hydroxide; phosphorus pentachloride; sulfuric acid; potassium tert-butylate; ammonia; water; In tetrahydrofuran; methanol; ethanol; dichloromethane;

Reference yield:

: 126802-75-3
10-chloro-8-(2-chlorophenyl)-6H-1,3-oxazepino<6,7-d><2>benzazepine-4-carboxylic acid ethyl ester

: 126802-78-6
8-chloro-6-(2-chlorophenyl)-1H,4H-pyrrolo<3,2-d><2>benzazepine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 42 percent / conc. sulfuric acid / ethanol / 0.08 h / Heating

2: 3.5 g / sodium hydroxyde, water / methanol / 4.5 h / Heating

3: 0.75 g / phosphorus pentachloride, ammonia gas / CH₂Cl₂ / 1 h / Ambient temperature

With sodium hydroxide; phosphorus pentachloride; sulfuric acid; ammonia; water; In methanol; ethanol; dichloromethane;