N¹-methyl-N²-(4-methylbenzoyl)-D-glutamine

Base Information

Chemical Name:N¹-methyl-N²-(4-methylbenzoyl)-D-glutamine
CAS No.:223467-00-3
Molecular Formula:C₁₄H₁₈N₂O₄
Molecular Weight:278.308
Hs Code.:

N<sup>1</sup>-methyl-N<sup>2</sup>-(4-methylbenzoyl)-D-glutamine

Synonyms:N¹-methyl-N²-(4-methylbenzoyl)-D-glutamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N¹-methyl-N²-(4-methylbenzoyl)-D-glutamine

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Technology Process of N¹-methyl-N²-(4-methylbenzoyl)-D-glutamine

There total 6 articles about N¹-methyl-N²-(4-methylbenzoyl)-D-glutamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 861819-92-3
benzyl N¹-methyl-N²-(4-methylbenzoyl)-D-glutaminate

: 223467-00-3
N¹-methyl-N²-(4-methylbenzoyl)-D-glutamine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 1h; atmospheric pressure;
DOI:10.1016/j.bmc.2005.04.051

Reference yield:

: (R)-4-Amino-4-methylcarbamoyl-butyric acid benzyl ester; hydrochloride

: 223467-00-3
N¹-methyl-N²-(4-methylbenzoyl)-D-glutamine

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / Et₃N / 0 - 20 °C

2: 91 percent / H₂ / Pd-C / ethanol / 1 h / 20 °C / atmospheric pressure

With hydrogen; triethylamine; palladium on activated charcoal; In ethanol;
DOI:10.1016/j.bmc.2005.04.051

Reference yield:

: 35793-73-8
N-(tert-butyloxycarbonyl)-γ-benzyl-D-glutamic acid

: 223467-00-3
N¹-methyl-N²-(4-methylbenzoyl)-D-glutamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: isobutyl chloroformate; N-methylmorpholine / tetrahydrofuran / cooling

1.2: 80 percent / tetrahydrofuran; H₂O / -20 - 20 °C

2.1: 100 percent / HCl / dioxane / 1 h / 20 °C

3.1: 65 percent / Et₃N / 0 - 20 °C

4.1: 91 percent / H₂ / Pd-C / ethanol / 1 h / 20 °C / atmospheric pressure

With 4-methyl-morpholine; hydrogenchloride; hydrogen; triethylamine; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol;
DOI:10.1016/j.bmc.2005.04.051