6-tert-butoxycarbonylamino-7-(tert-butyl-diphenyl-silanyloxy)-5-hydroxy-3-oxo-heptanoic acid ethyl ester

Base Information

Chemical Name:6-tert-butoxycarbonylamino-7-(tert-butyl-diphenyl-silanyloxy)-5-hydroxy-3-oxo-heptanoic acid ethyl ester
CAS No.:221302-53-0
Molecular Formula:C₃₀H₄₃NO₇Si
Molecular Weight:557.759
Hs Code.:

6-<i>tert</i>-butoxycarbonylamino-7-(<i>tert</i>-butyl-diphenyl-silanyloxy)-5-hydroxy-3-oxo-heptanoic acid ethyl ester

Synonyms:6-tert-butoxycarbonylamino-7-(tert-butyl-diphenyl-silanyloxy)-5-hydroxy-3-oxo-heptanoic acid ethyl ester

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Chemical Property of 6-tert-butoxycarbonylamino-7-(tert-butyl-diphenyl-silanyloxy)-5-hydroxy-3-oxo-heptanoic acid ethyl ester

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Technology Process of 6-tert-butoxycarbonylamino-7-(tert-butyl-diphenyl-silanyloxy)-5-hydroxy-3-oxo-heptanoic acid ethyl ester

There total 6 articles about 6-tert-butoxycarbonylamino-7-(tert-butyl-diphenyl-silanyloxy)-5-hydroxy-3-oxo-heptanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 221302-52-9
4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(3-ethoxycarbonyl-2-oxo-propyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 221302-53-0
6-tert-butoxycarbonylamino-7-(tert-butyl-diphenyl-silanyloxy)-5-hydroxy-3-oxo-heptanoic acid ethyl ester

Guidance literature:: With acetic acid; In water;
DOI:10.1016/S0040-4039(98)02614-8

Reference yield:

: 198417-69-5
tert-butyl [(1R)-2-(tert-butyldiphenylsilyloxy)-1-(hydroxymethyl)-ethyl]carbamate

: 221302-53-0
6-tert-butoxycarbonylamino-7-(tert-butyl-diphenyl-silanyloxy)-5-hydroxy-3-oxo-heptanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: Swern oxidation

3: 85 percent / PPTS

4: 1.) OsO₄, NMO; 2.) NaIO₄, silica gel

5: 77 percent / diethyl ether

6: 85 percent / PDC / CH₂Cl₂

7: 84 percent / AcOH / H₂O

With sodium periodate; osmium(VIII) oxide; dipyridinium dichromate; N-methyl-2-indolinone; pyridinium p-toluenesulfonate; silica gel; acetic acid; In diethyl ether; dichloromethane; water;
DOI:10.1016/S0040-4039(98)02614-8

Reference yield:

: 221302-50-7
4-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-5-(2-oxo-ethyl)-oxazolidine-3-carboxylic acid tert-butyl ester

: 221302-53-0
6-tert-butoxycarbonylamino-7-(tert-butyl-diphenyl-silanyloxy)-5-hydroxy-3-oxo-heptanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / diethyl ether

2: 85 percent / PDC / CH₂Cl₂

3: 84 percent / AcOH / H₂O

With dipyridinium dichromate; acetic acid; In diethyl ether; dichloromethane; water;
DOI:10.1016/S0040-4039(98)02614-8