3-cyclohexyl-2,3-epoxy-N,N-diisopropylpropanamide

Base Information

• Chemical Name: 3-cyclohexyl-2,3-epoxy-N,N-diisopropylpropanamide
• CAS No.: 642462-10-0
• Molecular Formula: C₁₅H₂₇NO₂
• Molecular Weight: 253.385
• Mol file: 642462-10-0.mol

Synonyms:3-cyclohexyl-2,3-epoxy-N,N-diisopropylpropanamide

Chemical Property of 3-cyclohexyl-2,3-epoxy-N,N-diisopropylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-cyclohexyl-2,3-epoxy-N,N-diisopropylpropanamide

There total 4 articles about 3-cyclohexyl-2,3-epoxy-N,N-diisopropylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-3-cyclohexyl-3-hydroxy-N,N-diisopropyl-propionamide → 3-cyclohexyl-2,3-epoxy-N,N-diisopropylpropanamide (642462-10-0)

Guidance literature:

With sodium hydride; In dichloromethane; at 25 ℃; for 2.5h;

DOI:10.1021/ol035757k

Reference yield:

N,N-diisopropylchloroacetamide (7403-66-9) → 3-cyclohexyl-2,3-epoxy-N,N-diisopropylpropanamide (642462-10-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: LDA / diethyl ether; tetrahydrofuran / 0.17 h / -78 °C

1.2: diethyl ether; tetrahydrofuran / 1 h / -78 °C

2.1: 567 mg / NaH / diethyl ether / 2.5 h / 25 °C

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether;

DOI:10.1002/ejoc.200300641

Reference yield:

cyclohexanecarbaldehyde (2043-61-0) → 3-cyclohexyl-2,3-epoxy-N,N-diisopropylpropanamide (642462-10-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: MeLi; diisopropylamine / tetrahydrofuran; diethyl ether / 0.17 h / -78 °C

1.2: tetrahydrofuran; diethyl ether / 1 h / -78 °C

2.1: sodium hydride / CH₂Cl₂ / 2.5 h / 25 °C

With methyllithium; sodium hydride; diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1021/ol035757k

upstream raw materials:

N,N-diisopropylchloroacetamide

cyclohexanecarbaldehyde

Refernces

• 1、 Concellon, Jose M.,Bardales, Eva. "Synthesis of aliphatic (E)-α,β-unsaturated amides with high diastereoselectivity from α,β-epoxyamides promoted by SmI 2/HMPA". . p. 1523 - 1526. Retrieved 2007/10/03.