2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-trifluoromethylphenyl]acetic acid

Base Information

Chemical Name:2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-trifluoromethylphenyl]acetic acid
CAS No.:1403380-92-6
Molecular Formula:C₂₂H₂₃F₃O₄
Molecular Weight:408.417
Hs Code.:

Synonyms:2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-trifluoromethylphenyl]acetic acid

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Chemical Property of 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-trifluoromethylphenyl]acetic acid

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Technology Process of 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-trifluoromethylphenyl]acetic acid

There total 6 articles about 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-trifluoromethylphenyl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1403381-65-6
methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-trifluoromethylphenyl]acetate

: 1403380-92-6
2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-trifluoromethylphenyl]acetic acid

Guidance literature:: methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-trifluoromethylphenyl]acetate; With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃;

With sodium dihydrogenphosphate; In tetrahydrofuran; water;

Reference yield:

: 1232403-45-0
1-(2-bromo-3-trifluoromethylphenyl)ethan-1-one

: 1403380-92-6
2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-trifluoromethylphenyl]acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: selenium(IV) oxide / ytterbium(III) triflate / 1,4-dioxane; water / 90 °C

1.2: 1 h / Reflux

2.1: perchloric acid / 2 h / -15 °C

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere; irradiated 200W

4.1: sodium hydroxide; water / tetrahydrofuran / 20 °C

With selenium(IV) oxide; perchloric acid; water; sodium carbonate; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ytterbium(III) triflate; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 177420-63-2
2-bromo-3-(trifluoromethyl)benzoic acid

: 1403380-92-6
2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-trifluoromethylphenyl]acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / 2 h / Reflux

2.1: triethylamine; magnesium chloride / acetonitrile / 2.5 h / 0 - 20 °C / Inert atmosphere

2.2: 20 °C

2.3: 3 h / Reflux

3.1: selenium(IV) oxide / ytterbium(III) triflate / 1,4-dioxane; water / 90 °C

3.2: 1 h / Reflux

4.1: perchloric acid / 2 h / -15 °C

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere; irradiated 200W

6.1: sodium hydroxide; water / tetrahydrofuran / 20 °C

With selenium(IV) oxide; thionyl chloride; perchloric acid; water; sodium carbonate; triethylamine; sodium hydroxide; magnesium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ytterbium(III) triflate; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile;