(3R)-3-[(2-chlorobenzoyl)amino]-N-[(1-pyridin-4-ylpiperidin-4-yl)methyl]-2,3-dihydro-1H-indene-5-carboxylic acid amide

Base Information

Chemical Name:(3R)-3-[(2-chlorobenzoyl)amino]-N-[(1-pyridin-4-ylpiperidin-4-yl)methyl]-2,3-dihydro-1H-indene-5-carboxylic acid amide
CAS No.:1365135-35-8
Molecular Formula:C₂₈H₂₉ClN₄O₂
Molecular Weight:489.017
Hs Code.:

Synonyms:(3R)-3-[(2-chlorobenzoyl)amino]-N-[(1-pyridin-4-ylpiperidin-4-yl)methyl]-2,3-dihydro-1H-indene-5-carboxylic acid amide

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Chemical Property of (3R)-3-[(2-chlorobenzoyl)amino]-N-[(1-pyridin-4-ylpiperidin-4-yl)methyl]-2,3-dihydro-1H-indene-5-carboxylic acid amide

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Technology Process of (3R)-3-[(2-chlorobenzoyl)amino]-N-[(1-pyridin-4-ylpiperidin-4-yl)methyl]-2,3-dihydro-1H-indene-5-carboxylic acid amide

There total 18 articles about (3R)-3-[(2-chlorobenzoyl)amino]-N-[(1-pyridin-4-ylpiperidin-4-yl)methyl]-2,3-dihydro-1H-indene-5-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: (1-(Pyridin-4-yl)piperidin-4-yl)methanamine dihydrochloride

: 1246506-61-5
(3R)-3-[(2-chloro-benzoyl)amino]-2,3-dihydro-1H-indene-5-carboxylic acid

: 1365135-35-8
(3R)-3-[(2-chlorobenzoyl)amino]-N-[(1-pyridin-4-ylpiperidin-4-yl)methyl]-2,3-dihydro-1H-indene-5-carboxylic acid amide

Guidance literature:: (3R)-3-[(2-chloro-benzoyl)amino]-2,3-dihydro-1H-indene-5-carboxylic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; In dichloromethane; at 0 - 20 ℃; for 0.25h;

(1-(Pyridin-4-yl)piperidin-4-yl)methanamine dihydrochloride; In dichloromethane; at 0 - 20 ℃; for 168h;

Reference yield:

: 177-11-7
4,4-ethylenedioxy-piperidine

: 1365135-35-8
(3R)-3-[(2-chlorobenzoyl)amino]-N-[(1-pyridin-4-ylpiperidin-4-yl)methyl]-2,3-dihydro-1H-indene-5-carboxylic acid amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 14 h / Reflux

2.1: hydrogenchloride / water / 14 h / 0 - 20 °C

3.1: potassium tert-butylate / 1,2-dimethoxyethane; ethanol / 2 h / 0 - 20 °C

4.1: dimethylsulfide borane complex; boron trifluoride diethyl etherate / tetrahydrofuran / 1 h / 0 °C / Reflux

5.1: triethylamine / dichloromethane / 2 h / 0 °C

6.1: acetyl chloride; methanol / 3 h / 20 °C / cooling with ice

7.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / benzotriazol-1-ol / dichloromethane / 0.25 h / 0 - 20 °C

7.2: 168 h / 0 - 20 °C

With hydrogenchloride; methanol; dimethylsulfide borane complex; boron trifluoride diethyl etherate; potassium tert-butylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; acetyl chloride; benzotriazol-1-ol; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; butan-1-ol;

Reference yield:

: 609-65-4
o-chlorobenzoyl chloride

: 1365135-35-8
(3R)-3-[(2-chlorobenzoyl)amino]-N-[(1-pyridin-4-ylpiperidin-4-yl)methyl]-2,3-dihydro-1H-indene-5-carboxylic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2.1: water; lithium hydroxide / methanol / 25 °C

2.2: pH 2

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / benzotriazol-1-ol / dichloromethane / 0.25 h / 0 - 20 °C

3.2: 168 h / 0 - 20 °C

With water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; benzotriazol-1-ol; In methanol; dichloromethane;