C₇₂H₁₂₇NO₁₃Si₃

Base Information

Chemical Name:C₇₂H₁₂₇NO₁₃Si₃
CAS No.:186417-29-8
Molecular Formula:C₇₂H₁₂₇NO₁₃Si₃
Molecular Weight:1299.06
Hs Code.:

C<sub>72</sub>H<sub>127</sub>NO<sub>13</sub>Si<sub>3</sub>

Synonyms:C₇₂H₁₂₇NO₁₃Si₃

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₇₂H₁₂₇NO₁₃Si₃

Chemical Property:

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Technology Process of C₇₂H₁₂₇NO₁₃Si₃

There total 34 articles about C₇₂H₁₂₇NO₁₃Si₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 186417-28-7
C₆₆H₁₁₃NO₁₃Si₂

: 186417-29-8
C₇₂H₁₂₇NO₁₃Si₃

Guidance literature:: With 2,6-dimethylpyridine; trifluoroacetic acid; In dichloromethane; at 0 ℃;
DOI:10.1021/ja963067o

Reference yield:

: 101977-00-8
(2R,3R,7S,10R)-7-Allyl-2,3,10-trimethyl-1,4,6-trioxa-spiro[4.5]decane

: 186417-29-8
C₇₂H₁₂₇NO₁₃Si₃

Guidance literature:: Multi-step reaction with 17 steps

1: 1.) O₃, 2.) PPh₃ / 1.) CH₂Cl₂, -78 deg C, 2.) room temperature, 17.5 h

2: 1.) CuCN, Bu₃SnH, 2.) n-BuLi / 1.) THF, -20 deg C to room temperature, 4 h, 2.) THF, -78 deg C, 45 min, 3.) THF, -78 deg C, 1 h

3: 89 percent / NaH, 15-crown-5

4: 95 percent / HOAc / tetrahydrofuran; H₂O

5: 99 percent / imidazole / dimethylformamide

6: 72 percent / DIBAL / tetrahydrofuran / -78 - 0 °C

7: 88 percent

8: 1.) LiHMDS / 1.) THF, -78 deg C to 0 deg C, 2.) THF, -78 deg C to 0 deg C

9: 78 percent

10: 77 percent / Dess-Martin periodinane, pyridine / CH₂Cl₂ / Ambient temperature

11: 80 percent / aq. HF / acetonitrile / Ambient temperature

12: 85 percent / Et₃N

13: 1.) Bu₃SnH, AIBN, 2.) I₂ / 1.) benzene, 90 deg C, 1 h, 2.) CH₂Cl₂, 0 deg C

14: 56 percent / LiI / pyridine / 16 h / 130 °C

15: 1.) EDS, DMAP, DMAP*HCl, 2.) i-Pr₂NEt, <(2-furyl)3P>2PdCl₂ / 1.) CH₂Cl₂, room temperature, 5 h, 2.) THF, DMF, room temperature, 7 h

16: 90 percent / TBAF, AcOH / tetrahydrofuran / 3 h / 0 °C

17: 84 percent / 2,6-lutidine, TFA / CH₂Cl₂ / 0 °C

With pyridine; 1H-imidazole; 2,6-dimethylpyridine; dmap; n-butyllithium; 15-crown-5; 2,2'-azobis(isobutyronitrile); dichlorobis(tri(2-furyl)phosphine)palladium(II); hydrogen fluoride; tetrabutyl ammonium fluoride; iodine; tri-n-butyl-tin hydride; 4-(dimethylamino)pyridine hydrochloride; sodium hydride; diisobutylaluminium hydride; Dess-Martin periodane; ozone; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; lithium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; pyridine; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja963067o

Reference yield:

: 18292-02-9
1-trimethylsilyl-1,3-pentadiyne

: 186417-29-8
C₇₂H₁₂₇NO₁₃Si₃

Guidance literature:: Multi-step reaction with 16 steps

1: 1.) CuCN, Bu₃SnH, 2.) n-BuLi / 1.) THF, -20 deg C to room temperature, 4 h, 2.) THF, -78 deg C, 45 min, 3.) THF, -78 deg C, 1 h

2: 89 percent / NaH, 15-crown-5

3: 95 percent / HOAc / tetrahydrofuran; H₂O

4: 99 percent / imidazole / dimethylformamide

5: 72 percent / DIBAL / tetrahydrofuran / -78 - 0 °C

6: 88 percent

7: 1.) LiHMDS / 1.) THF, -78 deg C to 0 deg C, 2.) THF, -78 deg C to 0 deg C

8: 78 percent

9: 77 percent / Dess-Martin periodinane, pyridine / CH₂Cl₂ / Ambient temperature

10: 80 percent / aq. HF / acetonitrile / Ambient temperature

11: 85 percent / Et₃N

12: 1.) Bu₃SnH, AIBN, 2.) I₂ / 1.) benzene, 90 deg C, 1 h, 2.) CH₂Cl₂, 0 deg C

13: 56 percent / LiI / pyridine / 16 h / 130 °C

14: 1.) EDS, DMAP, DMAP*HCl, 2.) i-Pr₂NEt, <(2-furyl)3P>2PdCl₂ / 1.) CH₂Cl₂, room temperature, 5 h, 2.) THF, DMF, room temperature, 7 h

15: 90 percent / TBAF, AcOH / tetrahydrofuran / 3 h / 0 °C

16: 84 percent / 2,6-lutidine, TFA / CH₂Cl₂ / 0 °C

With pyridine; 1H-imidazole; 2,6-dimethylpyridine; dmap; n-butyllithium; 15-crown-5; 2,2'-azobis(isobutyronitrile); dichlorobis(tri(2-furyl)phosphine)palladium(II); hydrogen fluoride; tetrabutyl ammonium fluoride; iodine; tri-n-butyl-tin hydride; 4-(dimethylamino)pyridine hydrochloride; sodium hydride; diisobutylaluminium hydride; Dess-Martin periodane; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; pyridine; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja963067o