Technology Process of (5E,2'Z)-1-methoxy-4-[6-(4-methyl-pent-2-enyloxy)-hex-5-enyloxymethyl]-benzene
There total 9 articles about (5E,2'Z)-1-methoxy-4-[6-(4-methyl-pent-2-enyloxy)-hex-5-enyloxymethyl]-benzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(l) iodide; 3,4,7,8-Tetramethyl-o-phenanthrolin; caesium carbonate;
In
o-xylene;
at 90 ℃;
for 60h;
DOI:10.1021/ol0702977
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 89 percent / potassium hydroxide / dimethylsulfoxide / 16 h / 0 - 20 °C
2: 96 percent / oxalyl chloride; dimethyl sulfoxide; triethylamine / CH2Cl2 / -78 - 0 °C
3: 72 percent / chromium(III) chloride; superhydride / tetrahydrofuran / 3 h / 0 °C
4: 81 percent / copper(I) iodide; 3,4,7,8-tetramethyl-1,10-phenanthroline; cesium carbonate / o-xylene / 60 h / 90 °C
With
potassium hydroxide; copper(l) iodide; oxalyl dichloride; 3,4,7,8-Tetramethyl-o-phenanthrolin; chromium(III) chloride; lithium triethylborohydride; caesium carbonate; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; dichloromethane; o-xylene; dimethyl sulfoxide;
4: Buchwald coupling;
DOI:10.1021/ol0702977
- Guidance literature:
-
Multi-step reaction with 3 steps
1: diethyl ether
2: 13.2 g / di-isobutylaluminium hydride / CH2Cl2; diethyl ether / 1 h / -78 °C
3: 81 percent / copper(I) iodide; 3,4,7,8-tetramethyl-1,10-phenanthroline; cesium carbonate / o-xylene / 60 h / 90 °C
With
copper(l) iodide; diisobutylaluminum hydride; 3,4,7,8-Tetramethyl-o-phenanthrolin; caesium carbonate;
In
diethyl ether; dichloromethane; o-xylene;
3: Buchwald coupling;
DOI:10.1021/ol0702977
