(2R,4R)-1-(4-Butoxy-benzenesulfonyl)-4-hydroxy-pyrrolidine-2-carboxylic acid

Base Information

Chemical Name:(2R,4R)-1-(4-Butoxy-benzenesulfonyl)-4-hydroxy-pyrrolidine-2-carboxylic acid
CAS No.:203994-92-7
Molecular Formula:C₁₅H₂₁NO₆S
Molecular Weight:343.401
Hs Code.:

Synonyms:(2R,4R)-1-(4-Butoxy-benzenesulfonyl)-4-hydroxy-pyrrolidine-2-carboxylic acid

Suppliers and Price of (2R,4R)-1-(4-Butoxy-benzenesulfonyl)-4-hydroxy-pyrrolidine-2-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4R)-1-(4-Butoxy-benzenesulfonyl)-4-hydroxy-pyrrolidine-2-carboxylic acid

Chemical Property:

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Technology Process of (2R,4R)-1-(4-Butoxy-benzenesulfonyl)-4-hydroxy-pyrrolidine-2-carboxylic acid

There total 1 articles about (2R,4R)-1-(4-Butoxy-benzenesulfonyl)-4-hydroxy-pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1138-56-3
4-butoxybenzene-sulfonyl chloride

: 2584-71-6,30724-02-8
cis-hydroxy-D-proline

: 203994-92-7
(2R,4R)-1-(4-Butoxy-benzenesulfonyl)-4-hydroxy-pyrrolidine-2-carboxylic acid

Guidance literature:: With dmap; triethylamine; In 1,4-dioxane; water; at 20 ℃; for 14h;
DOI:10.1021/jm9904699

Reference yield:

: 203994-92-7
(2R,4R)-1-(4-Butoxy-benzenesulfonyl)-4-hydroxy-pyrrolidine-2-carboxylic acid

: 204072-66-2
(2R,4S)-4-Amino-1-(4-butoxy-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / 14 h

2: Et₃N / CH₂Cl₂ / 20 °C

3: NaN₃ / dimethylformamide / 26 h / 55 °C

4: H₂; HCOOH / 10percent Pd/C / ethanol; tetrahydrofuran / 16 h / 2792.67 Torr

With formic acid; thionyl chloride; sodium azide; hydrogen; triethylamine; 10percent Pd/C; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm000246e

Reference yield:

: 203994-92-7
(2R,4R)-1-(4-Butoxy-benzenesulfonyl)-4-hydroxy-pyrrolidine-2-carboxylic acid

: (2R,4S)-4-Amino-1-(4-butoxy-benzenesulfonyl)-pyrrolidine-2-carboxylic acid hydroxyamide

Guidance literature:: Multi-step reaction with 5 steps

1: SOCl₂ / 14 h

2: Et₃N / CH₂Cl₂ / 20 °C

3: NaN₃ / dimethylformamide / 26 h / 55 °C

4: H₂; HCOOH / 10percent Pd/C / ethanol; tetrahydrofuran / 16 h / 2792.67 Torr

5: NH₂OK / methanol

With formic acid; thionyl chloride; sodium azide; hydroxylamine potassium salt; hydrogen; triethylamine; 10percent Pd/C; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm000246e