(2R,4aR,6S,7R,9S,10aS)-7-Benzyloxy-6-benzyloxymethyl-9-methyl-2-naphthalen-2-yl-octahydro-1,3,5-trioxa-benzocyclooctene

Base Information

Chemical Name:(2R,4aR,6S,7R,9S,10aS)-7-Benzyloxy-6-benzyloxymethyl-9-methyl-2-naphthalen-2-yl-octahydro-1,3,5-trioxa-benzocyclooctene
CAS No.:871912-64-0
Molecular Formula:C₃₅H₃₈O₅
Molecular Weight:538.684
Hs Code.:

Synonyms:(2R,4aR,6S,7R,9S,10aS)-7-Benzyloxy-6-benzyloxymethyl-9-methyl-2-naphthalen-2-yl-octahydro-1,3,5-trioxa-benzocyclooctene

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Chemical Property of (2R,4aR,6S,7R,9S,10aS)-7-Benzyloxy-6-benzyloxymethyl-9-methyl-2-naphthalen-2-yl-octahydro-1,3,5-trioxa-benzocyclooctene

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Technology Process of (2R,4aR,6S,7R,9S,10aS)-7-Benzyloxy-6-benzyloxymethyl-9-methyl-2-naphthalen-2-yl-octahydro-1,3,5-trioxa-benzocyclooctene

There total 4 articles about (2R,4aR,6S,7R,9S,10aS)-7-Benzyloxy-6-benzyloxymethyl-9-methyl-2-naphthalen-2-yl-octahydro-1,3,5-trioxa-benzocyclooctene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 66-99-9
β-naphthaldehyde

: 474125-30-9
(2R,3S,5R,7R,8S)-7-Benzyloxy-8-benzyloxymethyl-2-hydroxymethyl-5-methyl-oxocan-3-ol

: 871912-64-0
(2R,4aR,6S,7R,9S,10aS)-7-Benzyloxy-6-benzyloxymethyl-9-methyl-2-naphthalen-2-yl-octahydro-1,3,5-trioxa-benzocyclooctene

Guidance literature:: With pyridinium p-toluenesulfonate; In benzene; for 12h; Heating;
DOI:10.1016/j.tetlet.2005.09.164

Reference yield:

: (2R,4aR,6S,7R,9S,10aS)-6-Hydroxymethyl-9-methyl-2-phenyl-octahydro-1,3,5-trioxa-benzocycloocten-7-ol

: 871912-64-0
(2R,4aR,6S,7R,9S,10aS)-7-Benzyloxy-6-benzyloxymethyl-9-methyl-2-naphthalen-2-yl-octahydro-1,3,5-trioxa-benzocyclooctene

Guidance literature:: Multi-step reaction with 3 steps

1: tBuOK; TBAI / tetrahydrofuran / 0.5 h / 23 °C

2: ethanedithiol; BF₃Et₂O / CH₂Cl₂ / 0.5 h / -20 °C

3: 93 percent / PPTS / benzene / 12 h / Heating

With ethandithiol; boron trifluoride diethyl etherate; potassium tert-butylate; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1016/j.tetlet.2005.09.164

Reference yield:

: (2R,4aR,6S,7R,9S,10aS)-7-Benzyloxy-6-benzyloxymethyl-9-methyl-2-phenyl-octahydro-1,3,5-trioxa-benzocyclooctene

: 871912-64-0
(2R,4aR,6S,7R,9S,10aS)-7-Benzyloxy-6-benzyloxymethyl-9-methyl-2-naphthalen-2-yl-octahydro-1,3,5-trioxa-benzocyclooctene

Guidance literature:: Multi-step reaction with 2 steps

1: ethanedithiol; BF₃Et₂O / CH₂Cl₂ / 0.5 h / -20 °C

2: 93 percent / PPTS / benzene / 12 h / Heating

With ethandithiol; boron trifluoride diethyl etherate; pyridinium p-toluenesulfonate; In dichloromethane; benzene;
DOI:10.1016/j.tetlet.2005.09.164