2,4-bis-(tert-butyldimethylsilanyloxy)-3-[(R)-3-methyl-5-((R)-6-methyloctyliden)tetrahydropyran-2-(R)-yl]-5-phenylpyridine

Base Information

Chemical Name:2,4-bis-(tert-butyldimethylsilanyloxy)-3-[(R)-3-methyl-5-((R)-6-methyloctyliden)tetrahydropyran-2-(R)-yl]-5-phenylpyridine
CAS No.:648409-51-2
Molecular Formula:C₃₈H₆₃NO₃Si₂
Molecular Weight:638.094
Hs Code.:

Synonyms:2,4-bis-(tert-butyldimethylsilanyloxy)-3-[(R)-3-methyl-5-((R)-6-methyloctyliden)tetrahydropyran-2-(R)-yl]-5-phenylpyridine

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Chemical Property of 2,4-bis-(tert-butyldimethylsilanyloxy)-3-[(R)-3-methyl-5-((R)-6-methyloctyliden)tetrahydropyran-2-(R)-yl]-5-phenylpyridine

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Technology Process of 2,4-bis-(tert-butyldimethylsilanyloxy)-3-[(R)-3-methyl-5-((R)-6-methyloctyliden)tetrahydropyran-2-(R)-yl]-5-phenylpyridine

There total 13 articles about 2,4-bis-(tert-butyldimethylsilanyloxy)-3-[(R)-3-methyl-5-((R)-6-methyloctyliden)tetrahydropyran-2-(R)-yl]-5-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (E)-(S)-6-Methyl-octa-2,7-dien-1-ol

: 648409-51-2
2,4-bis-(tert-butyldimethylsilanyloxy)-3-[(R)-3-methyl-5-((R)-6-methyloctyliden)tetrahydropyran-2-(R)-yl]-5-phenylpyridine

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / H₂ / Pd/C

2: 68 percent / diethyl azodicarboxylate; PPh₃ / tetrahydrofuran

3: 93 percent / (NH₄)6Mo₇O₂₄*4H₂O; H₂O₂ / ethanol

4: LiHMDS

With ammonium heptamolybdate; hydrogen; dihydrogen peroxide; triphenylphosphine; lithium hexamethyldisilazane; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethanol; 4: Julia-Kocienski olefination;
DOI:10.1002/anie.200352268

Reference yield:

: 648409-57-8
(E)-(S)-6-Methyl-octa-2,7-dienoic acid methyl ester

: 648409-51-2
2,4-bis-(tert-butyldimethylsilanyloxy)-3-[(R)-3-methyl-5-((R)-6-methyloctyliden)tetrahydropyran-2-(R)-yl]-5-phenylpyridine

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / diisobutylaluminum hydride / diethyl ether

2: 88 percent / H₂ / Pd/C

3: 68 percent / diethyl azodicarboxylate; PPh₃ / tetrahydrofuran

4: 93 percent / (NH₄)6Mo₇O₂₄*4H₂O; H₂O₂ / ethanol

5: LiHMDS

With ammonium heptamolybdate; hydrogen; dihydrogen peroxide; diisobutylaluminium hydride; triphenylphosphine; lithium hexamethyldisilazane; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; 5: Julia-Kocienski olefination;
DOI:10.1002/anie.200352268

Reference yield:

: 97730-24-0
(6R)-6-methyloctan-1-ol

: 648409-51-2
2,4-bis-(tert-butyldimethylsilanyloxy)-3-[(R)-3-methyl-5-((R)-6-methyloctyliden)tetrahydropyran-2-(R)-yl]-5-phenylpyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / PPh₃; DEAD / tetrahydrofuran / 0.17 h

2: 93 percent / (NH₄)6Mo₇O₂₄*4H₂O; aq. H₂O₂ / ethanol / 18 h / 20 °C

3: LiHMDS / 1,2-dimethoxy-ethane / -78 °C

With ammonium heptamolybdate; dihydrogen peroxide; triphenylphosphine; lithium hexamethyldisilazane; diethylazodicarboxylate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; 1: Mitsunobu reaction / 3: Julia-Kocienski olefination;
DOI:10.1016/j.tet.2004.06.139