(S)-(E)-1-methoxy-3-phenyl-N-(1,2,3,4-tetrahydro-1-naphthyliden)-2-propylamine

Base Information

• Chemical Name: (S)-(E)-1-methoxy-3-phenyl-N-(1,2,3,4-tetrahydro-1-naphthyliden)-2-propylamine
• CAS No.: 77857-38-6
• Molecular Formula: C₂₀H₂₃NO
• Molecular Weight: 293.409
• Mol file: 77857-38-6.mol

Synonyms:(S)-(E)-1-methoxy-3-phenyl-N-(1,2,3,4-tetrahydro-1-naphthyliden)-2-propylamine

Chemical Property of (S)-(E)-1-methoxy-3-phenyl-N-(1,2,3,4-tetrahydro-1-naphthyliden)-2-propylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-(E)-1-methoxy-3-phenyl-N-(1,2,3,4-tetrahydro-1-naphthyliden)-2-propylamine

There total 4 articles about (S)-(E)-1-methoxy-3-phenyl-N-(1,2,3,4-tetrahydro-1-naphthyliden)-2-propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(S)-1-benzyl-2-methoxyethylamine (64715-80-6) + 3,4-dihydronaphthalene-1(2H)-one (529-34-0) → (S)-(E)-1-methoxy-3-phenyl-N-(1,2,3,4-tetrahydro-1-naphthyliden)-2-propylamine (77857-38-6)

Guidance literature:

With trifluoroacetic acid; In toluene; for 22h; Heating;

DOI:10.1016/S0040-4020(01)85702-1

Reference yield:

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → (S)-(E)-1-methoxy-3-phenyl-N-(1,2,3,4-tetrahydro-1-naphthyliden)-2-propylamine (77857-38-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 101 percent / SOCl₂ / Ambient temperature

2: 78 percent / NaBH₄ / aq. ethanol / 1.) room temperature, 4 h, 2.) reflux, 6 h, 3.) room temperature, overnight

3: KH

4: CF₃COOH / benzene / Heating

With sodium tetrahydroborate; thionyl chloride; potassium hydride; trifluoroacetic acid; In ethanol; benzene;

DOI:10.1021/ja00401a028

Reference yield:

L-Phenylalaninol (3182-95-4) → (S)-(E)-1-methoxy-3-phenyl-N-(1,2,3,4-tetrahydro-1-naphthyliden)-2-propylamine (77857-38-6)

Guidance literature:

Multi-step reaction with 2 steps

1: KH

2: CF₃COOH / benzene / Heating

With potassium hydride; trifluoroacetic acid; In benzene;

DOI:10.1021/ja00401a028

upstream raw materials:

(S)-1-benzyl-2-methoxyethylamine

3,4-dihydronaphthalene-1(2H)-one

L-phenylalanine

L-Phenylalaninol