(Z)-1-ethyl-5'-(4-fluorobenzylidene)-4,6-dimethoxy-5'H-spiro-[indoline-3,2'-thiophen]-2-one

Base Information

Chemical Name:(Z)-1-ethyl-5'-(4-fluorobenzylidene)-4,6-dimethoxy-5'H-spiro-[indoline-3,2'-thiophen]-2-one
CAS No.:1386262-26-5
Molecular Formula:C₂₂H₂₀FNO₃S
Molecular Weight:397.47
Hs Code.:

Synonyms:(Z)-1-ethyl-5'-(4-fluorobenzylidene)-4,6-dimethoxy-5'H-spiro-[indoline-3,2'-thiophen]-2-one

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Chemical Property of (Z)-1-ethyl-5'-(4-fluorobenzylidene)-4,6-dimethoxy-5'H-spiro-[indoline-3,2'-thiophen]-2-one

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Technology Process of (Z)-1-ethyl-5'-(4-fluorobenzylidene)-4,6-dimethoxy-5'H-spiro-[indoline-3,2'-thiophen]-2-one

There total 6 articles about (Z)-1-ethyl-5'-(4-fluorobenzylidene)-4,6-dimethoxy-5'H-spiro-[indoline-3,2'-thiophen]-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1386262-11-8
C₂₂H₂₂FNO₄S

: 1386262-26-5
(Z)-1-ethyl-5'-(4-fluorobenzylidene)-4,6-dimethoxy-5'H-spiro-[indoline-3,2'-thiophen]-2-one

Guidance literature:: With copper(ll) sulfate pentahydrate; toluene-4-sulfonic acid; In toluene; at 90 ℃; for 12h; regioselective reaction; Inert atmosphere;
DOI:10.1021/jo301039y

Reference yield:

: 159636-95-0
5-(4-Fluoro-benzyl)-thiophene-2-carbaldehyde

: 1386262-26-5
(Z)-1-ethyl-5'-(4-fluorobenzylidene)-4,6-dimethoxy-5'H-spiro-[indoline-3,2'-thiophen]-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: potassium permanganate / dichloromethane / Inert atmosphere

2: sulfuryl dichloride / Reflux; Inert atmosphere

3: triethylamine / dichloromethane / Inert atmosphere

4: sodium tetrahydroborate / methanol / Inert atmosphere

5: copper(ll) sulfate pentahydrate; toluene-4-sulfonic acid / toluene / 12 h / 90 °C / Inert atmosphere

With sodium tetrahydroborate; potassium permanganate; sulfuryl dichloride; copper(ll) sulfate pentahydrate; toluene-4-sulfonic acid; triethylamine; In methanol; dichloromethane; toluene;
DOI:10.1021/jo301039y

Reference yield:

: C₁₂H₆ClFO₂S

: 1386262-26-5
(Z)-1-ethyl-5'-(4-fluorobenzylidene)-4,6-dimethoxy-5'H-spiro-[indoline-3,2'-thiophen]-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / Inert atmosphere

2: sodium tetrahydroborate / methanol / Inert atmosphere

3: copper(ll) sulfate pentahydrate; toluene-4-sulfonic acid / toluene / 12 h / 90 °C / Inert atmosphere

With sodium tetrahydroborate; copper(ll) sulfate pentahydrate; toluene-4-sulfonic acid; triethylamine; In methanol; dichloromethane; toluene;
DOI:10.1021/jo301039y