4,4-Bis-[4-(4-carboxy-2-nitro-phenoxy)-3-methyl-phenyl]-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4,4-Bis-[4-(4-carboxy-2-nitro-phenoxy)-3-methyl-phenyl]-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:180712-97-4
Molecular Formula:C₃₈H₃₇N₃O₁₂
Molecular Weight:727.725
Hs Code.:

Synonyms:4,4-Bis-[4-(4-carboxy-2-nitro-phenoxy)-3-methyl-phenyl]-piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4,4-Bis-[4-(4-carboxy-2-nitro-phenoxy)-3-methyl-phenyl]-piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of 4,4-Bis-[4-(4-carboxy-2-nitro-phenoxy)-3-methyl-phenyl]-piperidine-1-carboxylic acid tert-butyl ester

There total 7 articles about 4,4-Bis-[4-(4-carboxy-2-nitro-phenoxy)-3-methyl-phenyl]-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 180712-96-3
4,4-Bis-[4-(4-methoxycarbonyl-2-nitro-phenoxy)-3-methyl-phenyl]-piperidine-1-carboxylic acid tert-butyl ester

: 180712-97-4
4,4-Bis-[4-(4-carboxy-2-nitro-phenoxy)-3-methyl-phenyl]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; methanol; water; for 4h; Ambient temperature;
DOI:10.1002/hlca.19960790403

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 180712-97-4
4,4-Bis-[4-(4-carboxy-2-nitro-phenoxy)-3-methyl-phenyl]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1M aq. NaOH / 4 h / Ambient temperature

2: 76 percent / K₂CO₃ / dimethylformamide / 14 h / Ambient temperature

3: 98 percent / KOH / H₂O; tetrahydrofuran; methanol / 4 h / Ambient temperature

With potassium hydroxide; sodium hydroxide; potassium carbonate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19960790403

Reference yield:

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 180712-97-4
4,4-Bis-[4-(4-carboxy-2-nitro-phenoxy)-3-methyl-phenyl]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / diethyl ether / ice cooling

2: 76 percent / K₂CO₃ / dimethylformamide / 14 h / Ambient temperature

3: 98 percent / KOH / H₂O; tetrahydrofuran; methanol / 4 h / Ambient temperature

With potassium hydroxide; potassium carbonate; In tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19960790403