(4S)-3-[3-methyl-1-(3-phenylpropyl)pyrrolidinyl-3-yl]-5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

• Chemical Name: (4S)-3-[3-methyl-1-(3-phenylpropyl)pyrrolidinyl-3-yl]-5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• CAS No.: 1404062-97-0
• Molecular Formula: C₃₀H₃₅N₃O₆
• Molecular Weight: 533.624
• Mol file: 1404062-97-0.mol

Synonyms:(4S)-3-[3-methyl-1-(3-phenylpropyl)pyrrolidinyl-3-yl]-5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Property of (4S)-3-[3-methyl-1-(3-phenylpropyl)pyrrolidinyl-3-yl]-5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S)-3-[3-methyl-1-(3-phenylpropyl)pyrrolidinyl-3-yl]-5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

There total 6 articles about (4S)-3-[3-methyl-1-(3-phenylpropyl)pyrrolidinyl-3-yl]-5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.3%

3-methyl-1-(3-phenylpropyl)pyrrolidin-3-ol (1404063-67-7) + (R)-5-(methoxycarbonyl)-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid (76093-33-9) → (4S)-3-[3-methyl-1-(3-phenylpropyl)pyrrolidinyl-3-yl]-5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (1404062-97-0)

Guidance literature:

(R)-5-(methoxycarbonyl)-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 25 ℃; Cooling with ice;

3-methyl-1-(3-phenylpropyl)pyrrolidin-3-ol; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; Cooling with ice;

Reference yield:

5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid (74936-72-4) → (4S)-3-[3-methyl-1-(3-phenylpropyl)pyrrolidinyl-3-yl]-5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (1404062-97-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: quinindine / methanol / 3 h / 90 °C / Reflux

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 25 °C / Cooling with ice

2.2: 25 °C / Cooling with ice

With oxalyl dichloride; quinindine; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

m-nifedipine (21881-77-6) → (4S)-3-[3-methyl-1-(3-phenylpropyl)pyrrolidinyl-3-yl]-5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (1404062-97-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: methanol; water; sodium hydroxide / 6 h / 70 °C

2.1: quinindine / methanol / 3 h / 90 °C / Reflux

3.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 25 °C / Cooling with ice

3.2: 25 °C / Cooling with ice

With methanol; oxalyl dichloride; water; quinindine; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

3-methyl-1-(3-phenylpropyl)pyrrolidin-3-ol

(R)-5-(methoxycarbonyl)-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid

3-nitro-benzaldehyde

m-nifedipine