Technology Process of 4-[4-(1-benzyl-1H-1,2,3-triazol-4-yl)-3-ethylphenyl]-1-[2-(1,4-dioxan-2-yl)ethyl]-5-ethyl-1H-1,2,3-triazole
There total 12 articles about 4-[4-(1-benzyl-1H-1,2,3-triazol-4-yl)-3-ethylphenyl]-1-[2-(1,4-dioxan-2-yl)ethyl]-5-ethyl-1H-1,2,3-triazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate;
In
methanol; water;
at 20 ℃;
DOI:10.1002/ejoc.201001531
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium azide / dimethyl sulfoxide / 45 °C
2.1: sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; copper(ll) sulfate pentahydrate / methanol; water / 20 - 60 °C
3.1: n-butyllithium / tetrahydrofuran; hexanes / 0.08 h / -78 °C / Inert atmosphere
3.2: 2 h / -78 - 20 °C / Inert atmosphere
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C
5.1: sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; copper(ll) sulfate pentahydrate / methanol; water / 20 °C
With
n-butyllithium; sodium azide; copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; tetrabutyl ammonium fluoride;
In
tetrahydrofuran; methanol; hexanes; water; dimethyl sulfoxide;
DOI:10.1002/ejoc.201001531
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 - 3 °C
1.2: 2 h / 0 °C
2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 96 h / 20 °C / Inert atmosphere
3.1: sodium hydroxide / toluene / 4 h / Reflux
4.1: sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; copper(ll) sulfate pentahydrate / methanol; water / 20 - 60 °C
5.1: n-butyllithium / tetrahydrofuran; hexanes / 0.08 h / -78 °C / Inert atmosphere
5.2: 2 h / -78 - 20 °C / Inert atmosphere
6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C
7.1: sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; copper(ll) sulfate pentahydrate / methanol; water / 20 °C
With
hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sodium nitrite;
In
tetrahydrofuran; methanol; hexanes; water; toluene;
1.1: Sandmeyer type reaction / 1.2: Sandmeyer type reaction / 2.1: Sonogashira coupling;
DOI:10.1002/ejoc.201001531
![1-[2-(1,4-dioxan-2-yl)ethyl]-5-ethyl-4-(3-ethyl-4-ethynylphenyl)-1H-1,2,3-triazole](/Databaselist/images/loading.webp)
