3-chloro-5-((1-((5-(1,1-difluoroethyl)-1-(4-methoxybenzyl)-6-oxo-1,6-dihydro pyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Base Information

Chemical Name:3-chloro-5-((1-((5-(1,1-difluoroethyl)-1-(4-methoxybenzyl)-6-oxo-1,6-dihydro pyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile
CAS No.:1591827-66-5
Molecular Formula:C₂₇H₁₉ClF₅N₅O₄
Molecular Weight:607.924
Hs Code.:

3-chloro-5-((1-((5-(1,1-difluoroethyl)-1-(4-methoxybenzyl)-6-oxo-1,6-dihydro pyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Synonyms:3-chloro-5-((1-((5-(1,1-difluoroethyl)-1-(4-methoxybenzyl)-6-oxo-1,6-dihydro pyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

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Chemical Property of 3-chloro-5-((1-((5-(1,1-difluoroethyl)-1-(4-methoxybenzyl)-6-oxo-1,6-dihydro pyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

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Technology Process of 3-chloro-5-((1-((5-(1,1-difluoroethyl)-1-(4-methoxybenzyl)-6-oxo-1,6-dihydro pyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

There total 15 articles about 3-chloro-5-((1-((5-(1,1-difluoroethyl)-1-(4-methoxybenzyl)-6-oxo-1,6-dihydro pyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1591827-65-4
3-((1-((5-acetyl-1-(4-methoxybenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)-5-chlorobenzonitrile

: 1591827-66-5
3-chloro-5-((1-((5-(1,1-difluoroethyl)-1-(4-methoxybenzyl)-6-oxo-1,6-dihydro pyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane;

Reference yield:

: 63001-30-9
methyl 6‐oxo‐1,6‐dihydropyridazine‐3‐carboxylate

: 1591827-66-5
3-chloro-5-((1-((5-(1,1-difluoroethyl)-1-(4-methoxybenzyl)-6-oxo-1,6-dihydro pyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Guidance literature:: Multi-step reaction with 8 steps

1: bromine

2: potassium carbonate / N,N-dimethyl-formamide

3: sodium tetrahydroborate / tetrahydrofuran; methanol

4: tetrahydrofuran

5: triethylamine / N,N-dimethyl-formamide

6: toluene

7: hydrogenchloride / 1,4-dioxane; ethyl acetate

8: diethylamino-sulfur trifluoride / dichloromethane

With hydrogenchloride; sodium tetrahydroborate; diethylamino-sulfur trifluoride; bromine; potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1591826-98-0
5-bromo-3-(4-methoxybenzyl)-6-(trifluoromethyl)pyrimidin-4(3H)-one

: 1591827-66-5
3-chloro-5-((1-((5-(1,1-difluoroethyl)-1-(4-methoxybenzyl)-6-oxo-1,6-dihydro pyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate

2: acetonitrile; water

3: triethylamine / N,N-dimethyl-formamide

4: toluene

5: hydrogenchloride / 1,4-dioxane; ethyl acetate

6: diethylamino-sulfur trifluoride / dichloromethane

With hydrogenchloride; diethylamino-sulfur trifluoride; potassium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;