{6-cyano-3-[2,2-difluoro-2-(pyridin-2-yl)ethylamino]-2-fluoro-phenyl}acetic acid ethyl ester

Base Information

Chemical Name:{6-cyano-3-[2,2-difluoro-2-(pyridin-2-yl)ethylamino]-2-fluoro-phenyl}acetic acid ethyl ester
CAS No.:780769-56-4
Molecular Formula:C₁₈H₁₆F₃N₃O₂
Molecular Weight:363.339
Hs Code.:

Synonyms:{6-cyano-3-[2,2-difluoro-2-(pyridin-2-yl)ethylamino]-2-fluoro-phenyl}acetic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of {6-cyano-3-[2,2-difluoro-2-(pyridin-2-yl)ethylamino]-2-fluoro-phenyl}acetic acid ethyl ester

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Technology Process of {6-cyano-3-[2,2-difluoro-2-(pyridin-2-yl)ethylamino]-2-fluoro-phenyl}acetic acid ethyl ester

There total 2 articles about {6-cyano-3-[2,2-difluoro-2-(pyridin-2-yl)ethylamino]-2-fluoro-phenyl}acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 780769-44-0
(6-cyano-2,3-difluoro-phenyl)-acetic acid ethyl ester

: 267875-68-3
2.2-Difluoro-2-(pyridin-2-yl)ethylamine

: 780769-56-4
{6-cyano-3-[2,2-difluoro-2-(pyridin-2-yl)ethylamino]-2-fluoro-phenyl}acetic acid ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 110 ℃; for 72h;
DOI:10.1016/j.bmcl.2008.03.087

Reference yield:

: 780769-56-4
{6-cyano-3-[2,2-difluoro-2-(pyridin-2-yl)ethylamino]-2-fluoro-phenyl}acetic acid ethyl ester

Guidance literature:

Reference yield: 100.0%

: 780769-56-4
{6-cyano-3-[2,2-difluoro-2-(pyridin-2-yl)ethylamino]-2-fluoro-phenyl}acetic acid ethyl ester

: 794498-03-6
{6-cyano-3-[2,2-difluoro-2-(pyridin-2-yl)ethylamino]-2-fluoro-phenyl}acetic acid

Guidance literature:: {6-cyano-3-[2,2-difluoro-2-(pyridin-2-yl)ethylamino]-2-fluoro-phenyl}acetic acid ethyl ester; With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 - 50 ℃; for 7.5h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; at 20 ℃; pH=~ 1;