ethyl α-ethoxyoxalyl-1-phenyl-5-(1-pyrryl)pyrazole-4-acetate

Base Information

• Chemical Name: ethyl α-ethoxyoxalyl-1-phenyl-5-(1-pyrryl)pyrazole-4-acetate
• CAS No.: 123705-09-9
• Molecular Formula: C₂₁H₂₁N₃O₅
• Molecular Weight: 395.415
• Mol file: 123705-09-9.mol

Synonyms:ethyl α-ethoxyoxalyl-1-phenyl-5-(1-pyrryl)pyrazole-4-acetate

Chemical Property of ethyl α-ethoxyoxalyl-1-phenyl-5-(1-pyrryl)pyrazole-4-acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of ethyl α-ethoxyoxalyl-1-phenyl-5-(1-pyrryl)pyrazole-4-acetate

There total 2 articles about ethyl α-ethoxyoxalyl-1-phenyl-5-(1-pyrryl)pyrazole-4-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl 1-phenyl-5-(1-pyrryl)pyrazole-4-acetate (123705-08-8) + oxalic acid diethyl ester (95-92-1) → ethyl α-ethoxyoxalyl-1-phenyl-5-(1-pyrryl)pyrazole-4-acetate (123705-09-9)

Guidance literature:

With ethanol; sodium; for 20h; Ambient temperature;

DOI:10.1002/jhet.5570260246

Reference yield:

1-phenyl-5-(1-pyrryl)pyrazole-4-acetic acid (116834-17-4) → ethyl α-ethoxyoxalyl-1-phenyl-5-(1-pyrryl)pyrazole-4-acetate (123705-09-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / 96 percent H₂SO₄ / Heating

2: 90 percent / Na, EtOH / 20 h / Ambient temperature

With ethanol; sulfuric acid; sodium;

DOI:10.1002/jhet.5570260246

Reference yield: 72.0%

ethyl α-ethoxyoxalyl-1-phenyl-5-(1-pyrryl)pyrazole-4-acetate (123705-09-9) → diethyl 1-phenyl-1H-pyrazolo<3,4-e>indolizine-4,5-dicarboxylate (123705-10-2)

Guidance literature:

With phosphorus pentoxide; In benzene; for 2.5h; Heating;

DOI:10.1002/jhet.5570260246

upstream raw materials:

ethyl 1-phenyl-5-(1-pyrryl)pyrazole-4-acetate

oxalic acid diethyl ester

1-phenyl-5-(1-pyrryl)pyrazole-4-acetic acid

Downstream raw materials:

diethyl 1-phenyl-1H-pyrazolo<3,4-e>indolizine-4,5-dicarboxylate

4,5-bis-(hydroxymethyl)-1-phenyl-1H-pyrazolo<3,4-e>indolizine

4,5-bis-(isopropylaminocarbonyloxymethyl)-1-phenyl-1H-pyrazolo<3,4-e>indolizine

4,5-bis-(cyclohexylaminocarbonyloxymethyl)-1-phenyl-1H-pyrazolo<3,4-e>indolizine