diethyl 2-(3-(2-propionyl-3-(3-(p-tolylamino)propoxy)phenoxy)propyl)malonate

Base Information

Chemical Name:diethyl 2-(3-(2-propionyl-3-(3-(p-tolylamino)propoxy)phenoxy)propyl)malonate
CAS No.:1365682-36-5
Molecular Formula:C₂₉H₃₉NO₇
Molecular Weight:513.631
Hs Code.:

Synonyms:diethyl 2-(3-(2-propionyl-3-(3-(p-tolylamino)propoxy)phenoxy)propyl)malonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl 2-(3-(2-propionyl-3-(3-(p-tolylamino)propoxy)phenoxy)propyl)malonate

Chemical Property:

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Technology Process of diethyl 2-(3-(2-propionyl-3-(3-(p-tolylamino)propoxy)phenoxy)propyl)malonate

There total 6 articles about diethyl 2-(3-(2-propionyl-3-(3-(p-tolylamino)propoxy)phenoxy)propyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.27%

: 1365681-88-4
diethyl 2-(3-(3-(3-chloropropoxy)-2-propionylphenoxy)propyl)malonate

: 106-49-0,12221-03-3
p-toluidine

: 1365682-36-5
diethyl 2-(3-(2-propionyl-3-(3-(p-tolylamino)propoxy)phenoxy)propyl)malonate

Guidance literature:: With potassium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 4h;
DOI:10.1016/j.bmc.2011.12.027

Reference yield:

: 108-46-3
recorcinol

: 1365682-36-5
diethyl 2-(3-(2-propionyl-3-(3-(p-tolylamino)propoxy)phenoxy)propyl)malonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / 0 - 8 °C

2.1: Reflux

3.1: aluminum (III) chloride / 170 °C

4.1: water; sodium hydroxide / Reflux

5.1: potassium carbonate / acetone / 6 h / Reflux

6.1: potassium tert-butylate / tetrahydrofuran / 3 h

6.2: 26 h / 80 - 90 °C

7.1: potassium iodide / N,N-dimethyl-formamide / 4 h / 80 °C

With aluminum (III) chloride; sulfuric acid; potassium tert-butylate; water; potassium carbonate; potassium iodide; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; acetone; 3.1: Fries rearrangement;
DOI:10.1016/j.bmc.2011.12.027

Reference yield:

: 1365681-80-6
1-(2,6-bis(3-chloropropoxy)phenyl)propan-1-one

: 1365682-36-5
diethyl 2-(3-(2-propionyl-3-(3-(p-tolylamino)propoxy)phenoxy)propyl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / 3 h

1.2: 26 h / 80 - 90 °C

2.1: potassium iodide / N,N-dimethyl-formamide / 4 h / 80 °C

With potassium tert-butylate; potassium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.12.027