2-(3-fluoro-4-methoxyphenyl)-2-(2-oxo-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-1(2H)-yl)acetic acid

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Chemical Name:2-(3-fluoro-4-methoxyphenyl)-2-(2-oxo-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-1(2H)-yl)acetic acid
CAS No.:1453848-38-8
Molecular Formula:C₂₃H₂₃FN₄O₅
Molecular Weight:454.458
Hs Code.:

Synonyms:2-(3-fluoro-4-methoxyphenyl)-2-(2-oxo-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-1(2H)-yl)acetic acid

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Chemical Property of 2-(3-fluoro-4-methoxyphenyl)-2-(2-oxo-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-1(2H)-yl)acetic acid

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Technology Process of 2-(3-fluoro-4-methoxyphenyl)-2-(2-oxo-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-1(2H)-yl)acetic acid

There total 5 articles about 2-(3-fluoro-4-methoxyphenyl)-2-(2-oxo-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-1(2H)-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 928136-81-6
methyl-2-bromo-2-(3-fluoro-4-methoxyphenyl)acetate

: 1453851-89-2
4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-pyridin-2(1H)-one

: 1453848-38-8
2-(3-fluoro-4-methoxyphenyl)-2-(2-oxo-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-1(2H)-yl)acetic acid

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 588-14-7
(3-fluoro-4-methoxyphenyl)acetic acid methyl ester

: 1453848-38-8
2-(3-fluoro-4-methoxyphenyl)-2-(2-oxo-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-1(2H)-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 17.5 h / 100 °C / Reflux

2: lithium hexamethyldisilazane / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

With N-Bromosuccinimide; lithium hexamethyldisilazane; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane;

Reference yield:

: 401815-98-3
2-fluoropyridin-4-ylboronic acid

: 1453848-38-8
2-(3-fluoro-4-methoxyphenyl)-2-(2-oxo-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-1(2H)-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 3 h / 80 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; iso-butanol / 100 °C / Microwave irradiation; Sealed tube

3: hydrogenchloride / water / Reflux

4: lithium hexamethyldisilazane / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; N-ethyl-N,N-diisopropylamine; iso-butanol; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; water; 1: |Suzuki Coupling;