tert-butyl 2-(tert-butoxycarbonylimino)-4-(N-para-fluorobenzylimino)aniline formate

Base Information

• Chemical Name: tert-butyl 2-(tert-butoxycarbonylimino)-4-(N-para-fluorobenzylimino)aniline formate
• CAS No.: 1432481-28-1
• Molecular Formula: C₂₃H₃₀FN₃O₄
• Molecular Weight: 431.507
• Mol file: 1432481-28-1.mol

Synonyms:tert-butyl 2-(tert-butoxycarbonylimino)-4-(N-para-fluorobenzylimino)aniline formate

Chemical Property of tert-butyl 2-(tert-butoxycarbonylimino)-4-(N-para-fluorobenzylimino)aniline formate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-(tert-butoxycarbonylimino)-4-(N-para-fluorobenzylimino)aniline formate

There total 5 articles about tert-butyl 2-(tert-butoxycarbonylimino)-4-(N-para-fluorobenzylimino)aniline formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.5%

di-tert-butyl dicarbonate (24424-99-5) + 4-N-[(4-fluorophenyl)methyl]benzene-1,2,4-triamine (491871-67-1) → tert-butyl 2-(tert-butoxycarbonylimino)-4-(N-para-fluorobenzylimino)aniline formate (1432481-28-1)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃;

DOI:10.1038/aps.2013.79

Reference yield:

1-N-[(4-fluorophenyl)methyl]-3-nitrobenzene-1,4-diamine (150812-21-8) → tert-butyl 2-(tert-butoxycarbonylimino)-4-(N-para-fluorobenzylimino)aniline formate (1432481-28-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / methanol / 3 h / 20 °C / 760.05 Torr

2: sodium hydrogencarbonate / tetrahydrofuran; water / 20 °C

With hydrogen; sodium hydrogencarbonate; In tetrahydrofuran; methanol; water;

DOI:10.1038/aps.2013.79

Reference yield:

2-nitro-1,4-phenylenediamine (5307-14-2,183870-67-9) → tert-butyl 2-(tert-butoxycarbonylimino)-4-(N-para-fluorobenzylimino)aniline formate (1432481-28-1)

Guidance literature:

Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / toluene / 3 h / Reflux

2: sodium tetrahydroborate / 1,4-dioxane; methanol / 2 h / 20 °C

3: hydrogen / methanol / 3 h / 20 °C / 760.05 Torr

4: sodium hydrogencarbonate / tetrahydrofuran; water / 20 °C

With sodium tetrahydroborate; hydrogen; sodium hydrogencarbonate; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; methanol; water; toluene;

DOI:10.1038/aps.2013.79

upstream raw materials:

2-nitro-1,4-phenylenediamine

4-fluorobenzaldehyde

2-amino-5-(4-fluorobenzylideneamino)nitrobenzene

di-tert-butyl dicarbonate

Downstream raw materials:

tert-butyl 2-(tert-butoxycarbonylimino)-4-(N-para-fluorobenzyl-N-allylimino)aniline formate

C₂₇H₃₆FN₃O₄

C₂₇H₃₆FN₃O₄

C₂₃H₂₈FN₃O₄