N-[N-(3,5-difluorophenylacetyl)-(S)-alanyl]-N-[4-(4-nitrophenyl)]thiazol-2-ylamine

Base Information

Chemical Name:N-[N-(3,5-difluorophenylacetyl)-(S)-alanyl]-N-[4-(4-nitrophenyl)]thiazol-2-ylamine
CAS No.:849145-46-6
Molecular Formula:C₂₀H₁₆F₂N₄O₄S
Molecular Weight:446.434
Hs Code.:

Synonyms:N-[N-(3,5-difluorophenylacetyl)-(S)-alanyl]-N-[4-(4-nitrophenyl)]thiazol-2-ylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[N-(3,5-difluorophenylacetyl)-(S)-alanyl]-N-[4-(4-nitrophenyl)]thiazol-2-ylamine

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Technology Process of N-[N-(3,5-difluorophenylacetyl)-(S)-alanyl]-N-[4-(4-nitrophenyl)]thiazol-2-ylamine

There total 1 articles about N-[N-(3,5-difluorophenylacetyl)-(S)-alanyl]-N-[4-(4-nitrophenyl)]thiazol-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 2-(N-(S)-alanyl)amino-4-(4-nitrophenyl)thiazole trifluoroacetic acid salt

: 105184-38-1
3,5-difluorophenyl acetic acid

: 849145-46-6
N-[N-(3,5-difluorophenylacetyl)-(S)-alanyl]-N-[4-(4-nitrophenyl)]thiazol-2-ylamine

Guidance literature:: 3,5-difluorophenyl acetic acid; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;

2-(N-(S)-alanyl)amino-4-(4-nitrophenyl)thiazole trifluoroacetic acid salt; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1039/b415090b

Reference yield: 90.0%

: 849145-46-6
N-[N-(3,5-difluorophenylacetyl)-(S)-alanyl]-N-[4-(4-nitrophenyl)]thiazol-2-ylamine

: 849145-47-7
N-[4-(4-amino-phenyl)-thiazol-2-yl]-2-[2-(3,5-difluoro-phenyl)-acetylamino]-propionamide

Guidance literature:: With iron; ammonium chloride; In ethanol; for 16h; Heating;
DOI:10.1039/b415090b

Reference yield:

: 849145-46-6
N-[N-(3,5-difluorophenylacetyl)-(S)-alanyl]-N-[4-(4-nitrophenyl)]thiazol-2-ylamine

: 849145-48-8
N-[N-(3,5-difluorophenylacetyl)-(S)-alanyl]-N-{4-[4-(N-pyridyl-3-carbonyl)aminophenyl]}thiazol-2-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / Fe; aq. NH₄Cl / ethanol / 16 h / Heating

2: 48 percent / pyridine / 18 h / Heating

With pyridine; iron; ammonium chloride; In ethanol;
DOI:10.1039/b415090b