(2E)-1-[(2R)-2-({4-[(2β,3α,5α,20R)-3,20-dihydroxypregnan-2-yl]piperazin-1-yl}carbonyl)pyrrolidin-1-yl]-3-phenylprop-2-en-1-one

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Chemical Name:(2E)-1-[(2R)-2-({4-[(2β,3α,5α,20R)-3,20-dihydroxypregnan-2-yl]piperazin-1-yl}carbonyl)pyrrolidin-1-yl]-3-phenylprop-2-en-1-one
CAS No.:1414928-29-2
Molecular Formula:C₃₉H₅₇N₃O₄
Molecular Weight:631.899
Hs Code.:

Synonyms:(2E)-1-[(2R)-2-({4-[(2β,3α,5α,20R)-3,20-dihydroxypregnan-2-yl]piperazin-1-yl}carbonyl)pyrrolidin-1-yl]-3-phenylprop-2-en-1-one

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Chemical Property of (2E)-1-[(2R)-2-({4-[(2β,3α,5α,20R)-3,20-dihydroxypregnan-2-yl]piperazin-1-yl}carbonyl)pyrrolidin-1-yl]-3-phenylprop-2-en-1-one

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Technology Process of (2E)-1-[(2R)-2-({4-[(2β,3α,5α,20R)-3,20-dihydroxypregnan-2-yl]piperazin-1-yl}carbonyl)pyrrolidin-1-yl]-3-phenylprop-2-en-1-one

There total 5 articles about (2E)-1-[(2R)-2-({4-[(2β,3α,5α,20R)-3,20-dihydroxypregnan-2-yl]piperazin-1-yl}carbonyl)pyrrolidin-1-yl]-3-phenylprop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 140-10-3
(E)-3-phenylacrylic acid

: 1414927-98-2
9H-fluoren-9-ylmethyl-4-[(2b,3a,5a,20R)-3,20-dihydroxypregnan-2-yl]piperazine-1-carboxylate

: 71989-31-6,109425-54-9,144829-96-9,101555-62-8
(R)-Pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester

: 1414928-29-2
(2E)-1-[(2R)-2-({4-[(2β,3α,5α,20R)-3,20-dihydroxypregnan-2-yl]piperazin-1-yl}carbonyl)pyrrolidin-1-yl]-3-phenylprop-2-en-1-one

Guidance literature:: 9H-fluoren-9-ylmethyl-4-[(2b,3a,5a,20R)-3,20-dihydroxypregnan-2-yl]piperazine-1-carboxylate; With 1H-imidazole; In dichloromethane; at 20 ℃; polystyrene diethylbutychlorosilyl resin Inert atmosphere;

With piperidine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

(E)-3-phenylacrylic acid; (R)-Pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester; Further stages;
DOI:10.1016/j.steroids.2012.07.012

Reference yield:

: 19290-93-8
(5α,20R)-pregn-2-en-20-ol

: 1414928-29-2
(2E)-1-[(2R)-2-({4-[(2β,3α,5α,20R)-3,20-dihydroxypregnan-2-yl]piperazin-1-yl}carbonyl)pyrrolidin-1-yl]-3-phenylprop-2-en-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: piperazine; water / 24 h / Inert atmosphere; Heating

3.1: sodium hydrogencarbonate / tetrahydrofuran; water / 20 °C

4.1: 1H-imidazole / dichloromethane / 20 °C / Inert atmosphere

4.2: 1 h / 20 °C / Inert atmosphere

With piperazine; 1H-imidazole; water; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.steroids.2012.07.012

Reference yield:

: 1414927-97-1
(2β,3α,5α,20R)-2-(piperazin-1-yl)-pregnane-3,20-diol

: 1414928-29-2
(2E)-1-[(2R)-2-({4-[(2β,3α,5α,20R)-3,20-dihydroxypregnan-2-yl]piperazin-1-yl}carbonyl)pyrrolidin-1-yl]-3-phenylprop-2-en-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 20 °C

2.1: 1H-imidazole / dichloromethane / 20 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

With 1H-imidazole; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.steroids.2012.07.012