2-((S)-2-((R)-2-nitro-1-phenylethyl)-3,4-dihydronaphthalen-1(2H)-ylidene)malononitrile

Base Information

Chemical Name:2-((S)-2-((R)-2-nitro-1-phenylethyl)-3,4-dihydronaphthalen-1(2H)-ylidene)malononitrile
CAS No.:870086-17-2
Molecular Formula:C₂₁H₁₇N₃O₂
Molecular Weight:343.385
Hs Code.:

Synonyms:2-((S)-2-((R)-2-nitro-1-phenylethyl)-3,4-dihydronaphthalen-1(2H)-ylidene)malononitrile

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Chemical Property of 2-((S)-2-((R)-2-nitro-1-phenylethyl)-3,4-dihydronaphthalen-1(2H)-ylidene)malononitrile

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Technology Process of 2-((S)-2-((R)-2-nitro-1-phenylethyl)-3,4-dihydronaphthalen-1(2H)-ylidene)malononitrile

There total 4 articles about 2-((S)-2-((R)-2-nitro-1-phenylethyl)-3,4-dihydronaphthalen-1(2H)-ylidene)malononitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 5153-67-3
nitrostyrene

: 2510-03-4
1,2,3,4-tetrahydro-1-naphthylidene malononitrile

: 870086-17-2
2-((S)-2-((R)-2-nitro-1-phenylethyl)-3,4-dihydronaphthalen-1(2H)-ylidene)malononitrile

Guidance literature:: hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; In acetone; at -40 ℃; for 38h;
DOI:10.1039/b514564c

Reference yield:

: 529-34-0
3,4-dihydronaphthalene-1(2H)-one

: 870086-17-2
2-((S)-2-((R)-2-nitro-1-phenylethyl)-3,4-dihydronaphthalen-1(2H)-ylidene)malononitrile

Guidance literature:: Multi-step reaction with 2 steps

1: Al₂O₃

2: 84 percent / (DHQD)2PYR / acetone / 38 h / -40 °C

With aluminum oxide; hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; In acetone; 1: Knoevenagel condensation / 2: Michael reaction;
DOI:10.1039/b514564c

Reference yield:

: 5153-67-3
nitrostyrene

: 2510-03-4
1,2,3,4-tetrahydro-1-naphthylidene malononitrile

: 2-((R)-2-((S)-2-nitro-1-phenylethyl)-3,4-dihydronaphthalen-1(2H)-ylidene)malononitrile

: 870086-17-2
2-((S)-2-((R)-2-nitro-1-phenylethyl)-3,4-dihydronaphthalen-1(2H)-ylidene)malononitrile

Guidance literature:: With hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; In dichloromethane; at -40 ℃; for 70h; Further Variations:; Reagents; Temperatures; reaction times; Product distribution;
DOI:10.1021/ol052283b