ethyl 2-((8-(benzyloxy)-5-(5-(tert-butoxycarbonylamino)-N-methyl-pentylsulfonamido)-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoate

Base Information

Chemical Name:ethyl 2-((8-(benzyloxy)-5-(5-(tert-butoxycarbonylamino)-N-methyl-pentylsulfonamido)-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoate
CAS No.:1292211-30-3
Molecular Formula:C₃₇H₄₄FN₅O₈S
Molecular Weight:737.849
Hs Code.:

ethyl 2-((8-(benzyloxy)-5-(5-(tert-butoxycarbonylamino)-N-methyl-pentylsulfonamido)-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoate

Synonyms:ethyl 2-((8-(benzyloxy)-5-(5-(tert-butoxycarbonylamino)-N-methyl-pentylsulfonamido)-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoate

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Chemical Property of ethyl 2-((8-(benzyloxy)-5-(5-(tert-butoxycarbonylamino)-N-methyl-pentylsulfonamido)-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoate

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Technology Process of ethyl 2-((8-(benzyloxy)-5-(5-(tert-butoxycarbonylamino)-N-methyl-pentylsulfonamido)-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoate

There total 10 articles about ethyl 2-((8-(benzyloxy)-5-(5-(tert-butoxycarbonylamino)-N-methyl-pentylsulfonamido)-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1292211-02-9
2-(aminomethyl)-5-fluorobenzoic acid ethyl ester hydrochloride

: 1292211-29-0
8-(benzyloxy)-5-(5-(tert-butoxycarbonylamino)-N-methylpentylsulfonamido)-1,6-naphthyridine-7-carboxylic acid

: 1292211-30-3
ethyl 2-((8-(benzyloxy)-5-(5-(tert-butoxycarbonylamino)-N-methyl-pentylsulfonamido)-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoate

Guidance literature:: 8-(benzyloxy)-5-(5-(tert-butoxycarbonylamino)-N-methylpentylsulfonamido)-1,6-naphthyridine-7-carboxylic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.0833333h;

2-(aminomethyl)-5-fluorobenzoic acid ethyl ester hydrochloride; In dichloromethane; at 20 ℃;

Reference yield:

: 410544-37-5
5-bromo-8-hydroxy-[1,6]naphthyridine-7-carboxylic acid methyl ester

: 1292211-30-3
ethyl 2-((8-(benzyloxy)-5-(5-(tert-butoxycarbonylamino)-N-methyl-pentylsulfonamido)-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / chloroform / 2 h / 20 - 50 °C

2.1: [2,2]bipyridinyl / copper(II) oxide / N,N-dimethyl-formamide / 4 h / 120 °C / Inert atmosphere

3.1: sodium methylate / N,N-dimethyl-formamide; methanol / 25 - 50 °C

4.1: caesium carbonate / N,N-dimethyl-formamide

5.1: sodium hydroxide; water / methanol / 20 - 50 °C

5.2: pH 6.7

6.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 0.08 h / 20 °C

6.2: 20 °C

With [2,2]bipyridinyl; water; sodium methylate; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; copper(II) oxide; In methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 410545-60-7
methyl 5-bromo-8-p-toluenesulfonyloxy-1,6-naphthyridine-7-carboxylate

: 1292211-30-3
ethyl 2-((8-(benzyloxy)-5-(5-(tert-butoxycarbonylamino)-N-methyl-pentylsulfonamido)-1,6-naphthyridine-7-carboxamido)methyl)-5-fluorobenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: [2,2]bipyridinyl / copper(II) oxide / N,N-dimethyl-formamide / 4 h / 120 °C / Inert atmosphere

2.1: sodium methylate / N,N-dimethyl-formamide; methanol / 25 - 50 °C

3.1: caesium carbonate / N,N-dimethyl-formamide

4.1: sodium hydroxide; water / methanol / 20 - 50 °C

4.2: pH 6.7

5.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 0.08 h / 20 °C

5.2: 20 °C

With [2,2]bipyridinyl; water; sodium methylate; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; copper(II) oxide; In methanol; dichloromethane; N,N-dimethyl-formamide;