Naphtho[2,1,8-def]quinolin-2(1H)-one

Base Information

• Chemical Name: Naphtho[2,1,8-def]quinolin-2(1H)-one
• CAS No.: 105360-93-8
• Molecular Formula: C₁₅H₉NO
• Molecular Weight: 219.243
• Mol file: 105360-93-8.mol

Synonyms:1-Aza-2-hydroxypyrene

Chemical Property of Naphtho[2,1,8-def]quinolin-2(1H)-one

Chemical Property:

• Vapor Pressure: 4.1E-12mmHg at 25°C
• Boiling Point: 549.2°C at 760 mmHg
• Flash Point: 323.5°C
• Density: 1.37g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Naphtho[2,1,8-def]quinolin-2(1H)-one

There total 6 articles about Naphtho[2,1,8-def]quinolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

3,3a,4,5-tetrahydro-1-azapyren-2(1H)-one (106835-28-3) → 1-azapyren-2-ol (105360-93-8)

Guidance literature:

palladium on activated charcoal; at 230 - 320 ℃; for 1h;

Reference yield:

2,2a,3,4-tetrahydrocyclopentaphenalen-1-one (54100-63-9) → 1-azapyren-2-ol (105360-93-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / NH₂OH*HCl, aq. 50percent KOH / methanol / 4 h / Heating

2: 83 percent / (C₂H₅)3N / CH₂Cl₂ / 0.5 h / -20 °C

3: 51 percent / AlCl₃ / CH₂Cl₂ / 6 h / Heating

4: 61 percent / 10percent Pd on carbon / 1 h / 230 - 320 °C

With potassium hydroxide; aluminium trichloride; hydroxylamine hydrochloride; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;

Reference yield:

2-(2,3-dihydrophenalenyl)acetic acid (54100-62-8) → 1-azapyren-2-ol (105360-93-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 80 percent / HF / 24 h

2: 95 percent / NH₂OH*HCl, aq. 50percent KOH / methanol / 4 h / Heating

3: 83 percent / (C₂H₅)3N / CH₂Cl₂ / 0.5 h / -20 °C

4: 51 percent / AlCl₃ / CH₂Cl₂ / 6 h / Heating

5: 61 percent / 10percent Pd on carbon / 1 h / 230 - 320 °C

With potassium hydroxide; aluminium trichloride; hydrogen fluoride; hydroxylamine hydrochloride; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;

upstream raw materials:

3,3a,4,5-tetrahydro-1-azapyren-2(1H)-one

2,2a,3,4-tetrahydrocyclopentaphenalen-1-one

2-(2,3-dihydrophenalenyl)acetic acid

ethyl 2-(2,3-dihydrophenalenyl)acetate

Refernces