(1S,2S,5R)-2-isopropyl-1-(3-methoxycarbonyloxy-1-propynyl)-5-methylcyclohexanol

Base Information

Chemical Name:(1S,2S,5R)-2-isopropyl-1-(3-methoxycarbonyloxy-1-propynyl)-5-methylcyclohexanol
CAS No.:530158-34-0
Molecular Formula:C₁₅H₂₄O₄
Molecular Weight:268.353
Hs Code.:

Synonyms:(1S,2S,5R)-2-isopropyl-1-(3-methoxycarbonyloxy-1-propynyl)-5-methylcyclohexanol

Suppliers and Price of (1S,2S,5R)-2-isopropyl-1-(3-methoxycarbonyloxy-1-propynyl)-5-methylcyclohexanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2S,5R)-2-isopropyl-1-(3-methoxycarbonyloxy-1-propynyl)-5-methylcyclohexanol

Chemical Property:

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Technology Process of (1S,2S,5R)-2-isopropyl-1-(3-methoxycarbonyloxy-1-propynyl)-5-methylcyclohexanol

There total 2 articles about (1S,2S,5R)-2-isopropyl-1-(3-methoxycarbonyloxy-1-propynyl)-5-methylcyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10458-14-7,14073-97-3,17627-49-5,7786-64-3
(2R,5S)-menthone

: 530158-34-0
(1S,2S,5R)-2-isopropyl-1-(3-methoxycarbonyloxy-1-propynyl)-5-methylcyclohexanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: TMEDA; n-BuLi / tetrahydrofuran / 1 h / -78 °C

1.2: 68 percent / tetrahydrofuran / 1 h / -78 °C

2.1: 91 percent / TsOH*H₂O; MeOH / 2 h / 20 °C

3.1: 95 percent / pyridine / CH₂Cl₂ / 1 h / 0 °C

With pyridine; methanol; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja0340681

Reference yield:

: 530158-82-8
(1S,2S,5R)-2-isopropyl-5-methyl-1-[3-(2H-tetrahydropyran-2-yloxy)-1-propynyl]cyclohexanol

: 530158-34-0
(1S,2S,5R)-2-isopropyl-1-(3-methoxycarbonyloxy-1-propynyl)-5-methylcyclohexanol

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / TsOH*H₂O; MeOH / 2 h / 20 °C

2: 95 percent / pyridine / CH₂Cl₂ / 1 h / 0 °C

With pyridine; methanol; toluene-4-sulfonic acid; In dichloromethane;
DOI:10.1021/ja0340681

Reference yield:

: 150-76-5
4-methoxy-phenol

: 530158-34-0
(1S,2S,5R)-2-isopropyl-1-(3-methoxycarbonyloxy-1-propynyl)-5-methylcyclohexanol

: (1S,2S)-1,2-carbonyldioxy-2-[1-(4-methoxyphenoxy)vinyl]ethane-1-spiro-[(1'S,2'S,5'R)-2-isopropenyl-5-methyl]cyclohexane

: (1S,2R)-1,2-carbonyldioxy-2-[1-(4-methoxyphenoxy)vinyl]ethane-1-spiro-[(1'S,2'S,5'R)-2-isopropenyl-5-methyl]cyclohexane

Guidance literature:: With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 1,2-bis-(diphenylphosphino)ethane; In 1,4-dioxane; at 50 ℃; for 16h; CO₂ atmosphere;
DOI:10.1021/ja0340681